International Collaborative Ovarian Neoplasm trial 1: a randomized trial of adjuvant chemotherapy in women with early-stage ovarian cancer

Nicoletta Colombo, David Guthrie, Stefania Chiari, Mahesh Parmar, Wendi Qian, Ann Marie Swart, Valter Torri, Christopher Williams, Andrea Lissoni, Cristina Bonazzi, International Collaborative Ovarian Neoplasm (ICON) collaborators

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232 Citations (Scopus)


The question of whether platinum-based adjuvant chemotherapy can improve outcomes in patients with early-stage epithelial ovarian cancer is an important one. We carried out a multicenter, open randomized trial to determine whether adjuvant chemotherapy would improve overall survival and prolong recurrence-free survival in women with early-stage epithelial ovarian cancer.
Original languageEnglish
Pages (from-to)125-32
Number of pages8
JournalJournal of the National Cancer Institute
Issue number2
Publication statusPublished - 15 Jan 2003


  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Carboplatin
  • Carcinoma
  • Chemotherapy, Adjuvant
  • Cisplatin
  • Confidence Intervals
  • Disease-Free Survival
  • Drug Administration Schedule
  • Female
  • Humans
  • International Cooperation
  • Middle Aged
  • Neoplasm Staging
  • Observation
  • Odds Ratio
  • Ovarian Neoplasms
  • Survival Analysis
  • Treatment Outcome

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