International consensus statement on allergy and rhinology: Olfaction

Zara M. Patel; Eric H. Holbrook; Justin H. Turner; Nithin Adappa; Mark W. Albers; Aytug Altundag; Simone Appenzeller; Richard M. Costanzo; Ilona Croy; Greg Davis; Puya Dehgani-Mobaraki; Richard L. Doty; Valerie B. Duffy; Bradley J. Goldstein; David A.  Gudis; Antje Haehner; Thomas S. Higgins; Claire Hopkins; Caroline Huart; Thomas Hummel; Kawinyarat Jitaroon; Robert C. Kern; Ashoke R. Khanwalkar; Masayoshi Kobayashi; Kenji Kondo; Andrew P. Lane; Matthias Lechner; Donald A. Leopold; Joshua M.  Levy; Michael J. Marmura; Lisha McLelland; Paul J. Moberg; Cristian A. Mueller; Sagar U. Nigwekar; Erin O’Brien; Robert Pellegrino; Carl Philpott; Jayant M. Pinto; Evan R. Reiter; David R. Roalf; Nicholas R. Rowan; Rodney J.  Schlosser; James Schwob; Allen M. Seiden; Timothy L.  Smith; Zachary M. Soler; Leigh  Sowerby; Miwa Takaki; Bruce K.  Tan; Andrew Thamboo; Bozena Wrobel; Carol H. Yan

doi:10.1002/alr.22929

International consensus statement on allergy and rhinology: Olfaction

Zara M. Patel, Eric H. Holbrook, Justin H. Turner, Nithin Adappa, Mark W. Albers, Aytug Altundag, Simone Appenzeller, Richard M. Costanzo, Ilona Croy, Greg Davis, Puya Dehgani-Mobaraki, Richard L. Doty, Valerie B. Duffy, Bradley J. Goldstein, David A. Gudis, Antje Haehner, Thomas S. Higgins, Claire Hopkins, Caroline Huart, Thomas HummelKawinyarat Jitaroon, Robert C. Kern, Ashoke R. Khanwalkar, Masayoshi Kobayashi, Kenji Kondo, Andrew P. Lane, Matthias Lechner, Donald A. Leopold, Joshua M. Levy, Michael J. Marmura, Lisha McLelland, Paul J. Moberg, Cristian A. Mueller, Sagar U. Nigwekar, Erin O’Brien, Robert Pellegrino, Carl Philpott, Jayant M. Pinto, Evan R. Reiter, David R. Roalf, Nicholas R. Rowan, Rodney J. Schlosser, James Schwob, Allen M. Seiden, Timothy L. Smith, Zachary M. Soler, Leigh Sowerby, Miwa Takaki, Bruce K. Tan, Andrew Thamboo, Bozena Wrobel, Carol H. Yan

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Abstract

Background: The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O).

Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus.

Results: The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies.

Conclusion: This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

Original language	English
Pages (from-to)	327-680
Number of pages	354
Journal	International Forum of Allergy & Rhinology
Volume	12
Issue number	4
Early online date	3 Apr 2022
DOIs	https://doi.org/10.1002/alr.22929
Publication status	Published - Apr 2022

Keywords

anosmia
evidence-based medicine
hyposmia
loss of smell
olfaction
olfactory dysfunction
olfactory loss
parosmia
phantosmia
systematic review

Access to Document

10.1002/alr.22929

Accepted_ManuscriptAccepted author manuscript, 3.83 MB

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Patel, Z. M., Holbrook, E. H., Turner, J. H., Adappa, N., Albers, M. W., Altundag, A., Appenzeller, S., Costanzo, R. M., Croy, I., Davis, G., Dehgani-Mobaraki, P., Doty, R. L., Duffy, V. B., Goldstein, B. J., Gudis, D. A., Haehner, A., Higgins, T. S., Hopkins, C., Huart, C., ... Yan, C. H. (2022). International consensus statement on allergy and rhinology: Olfaction. International Forum of Allergy & Rhinology, 12(4), 327-680. https://doi.org/10.1002/alr.22929

@article{eef3cd20475849bfa0e75240033e6d1f,

title = "International consensus statement on allergy and rhinology: Olfaction",

abstract = "Background: The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O).Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus.Results: The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies.Conclusion: This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.",

keywords = "anosmia, evidence-based medicine, hyposmia, loss of smell, olfaction, olfactory dysfunction, olfactory loss, parosmia, phantosmia, systematic review",

author = "Patel, {Zara M.} and Holbrook, {Eric H.} and Turner, {Justin H.} and Nithin Adappa and Albers, {Mark W.} and Aytug Altundag and Simone Appenzeller and Costanzo, {Richard M.} and Ilona Croy and Greg Davis and Puya Dehgani-Mobaraki and Doty, {Richard L.} and Duffy, {Valerie B.} and Goldstein, {Bradley J.} and Gudis, {David A.} and Antje Haehner and Higgins, {Thomas S.} and Claire Hopkins and Caroline Huart and Thomas Hummel and Kawinyarat Jitaroon and Kern, {Robert C.} and Khanwalkar, {Ashoke R.} and Masayoshi Kobayashi and Kenji Kondo and Lane, {Andrew P.} and Matthias Lechner and Leopold, {Donald A.} and Levy, {Joshua M.} and Marmura, {Michael J.} and Lisha McLelland and Moberg, {Paul J.} and Mueller, {Cristian A.} and Nigwekar, {Sagar U.} and Erin O{\textquoteright}Brien and Robert Pellegrino and Carl Philpott and Pinto, {Jayant M.} and Reiter, {Evan R.} and Roalf, {David R.} and Rowan, {Nicholas R.} and Schlosser, {Rodney J.} and James Schwob and Seiden, {Allen M.} and Smith, {Timothy L.} and Soler, {Zachary M.} and Leigh Sowerby and Miwa Takaki and Tan, {Bruce K.} and Andrew Thamboo and Bozena Wrobel and Yan, {Carol H.}",

year = "2022",

month = apr,

doi = "10.1002/alr.22929",

language = "English",

volume = "12",

pages = "327--680",

journal = "International Forum of Allergy & Rhinology",

issn = "2042-6976",

publisher = "Wiley",

number = "4",

}

Patel, ZM, Holbrook, EH, Turner, JH, Adappa, N, Albers, MW, Altundag, A, Appenzeller, S, Costanzo, RM, Croy, I, Davis, G, Dehgani-Mobaraki, P, Doty, RL, Duffy, VB, Goldstein, BJ, Gudis, DA, Haehner, A, Higgins, TS, Hopkins, C, Huart, C, Hummel, T, Jitaroon, K, Kern, RC, Khanwalkar, AR, Kobayashi, M, Kondo, K, Lane, AP, Lechner, M, Leopold, DA, Levy, JM, Marmura, MJ, McLelland, L, Moberg, PJ, Mueller, CA, Nigwekar, SU, O’Brien, E, Pellegrino, R, Philpott, C, Pinto, JM, Reiter, ER, Roalf, DR, Rowan, NR, Schlosser, RJ, Schwob, J, Seiden, AM, Smith, TL, Soler, ZM, Sowerby, L, Takaki, M, Tan, BK, Thamboo, A, Wrobel, B & Yan, CH 2022, 'International consensus statement on allergy and rhinology: Olfaction', International Forum of Allergy & Rhinology, vol. 12, no. 4, pp. 327-680. https://doi.org/10.1002/alr.22929

TY - JOUR

T1 - International consensus statement on allergy and rhinology: Olfaction

AU - Patel, Zara M.

AU - Holbrook, Eric H.

AU - Turner, Justin H.

AU - Adappa, Nithin

AU - Albers, Mark W.

AU - Altundag, Aytug

AU - Appenzeller, Simone

AU - Costanzo, Richard M.

AU - Croy, Ilona

AU - Davis, Greg

AU - Dehgani-Mobaraki, Puya

AU - Doty, Richard L.

AU - Duffy, Valerie B.

AU - Goldstein, Bradley J.

AU - Gudis, David A.

AU - Haehner, Antje

AU - Higgins, Thomas S.

AU - Hopkins, Claire

AU - Huart, Caroline

AU - Hummel, Thomas

AU - Jitaroon, Kawinyarat

AU - Kern, Robert C.

AU - Khanwalkar, Ashoke R.

AU - Kobayashi, Masayoshi

AU - Kondo, Kenji

AU - Lane, Andrew P.

AU - Lechner, Matthias

AU - Leopold, Donald A.

AU - Levy, Joshua M.

AU - Marmura, Michael J.

AU - McLelland, Lisha

AU - Moberg, Paul J.

AU - Mueller, Cristian A.

AU - Nigwekar, Sagar U.

AU - O’Brien, Erin

AU - Pellegrino, Robert

AU - Philpott, Carl

AU - Pinto, Jayant M.

AU - Reiter, Evan R.

AU - Roalf, David R.

AU - Rowan, Nicholas R.

AU - Schlosser, Rodney J.

AU - Schwob, James

AU - Seiden, Allen M.

AU - Smith, Timothy L.

AU - Soler, Zachary M.

AU - Sowerby, Leigh

AU - Takaki, Miwa

AU - Tan, Bruce K.

AU - Thamboo, Andrew

AU - Wrobel, Bozena

AU - Yan, Carol H.

PY - 2022/4

Y1 - 2022/4

N2 - Background: The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O).Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus.Results: The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies.Conclusion: This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

AB - Background: The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O).Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus.Results: The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies.Conclusion: This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

KW - anosmia

KW - evidence-based medicine

KW - hyposmia

KW - loss of smell

KW - olfaction

KW - olfactory dysfunction

KW - olfactory loss

KW - parosmia

KW - phantosmia

KW - systematic review

UR - http://www.scopus.com/inward/record.url?scp=85127480132&partnerID=8YFLogxK

U2 - 10.1002/alr.22929

DO - 10.1002/alr.22929

M3 - Article

VL - 12

SP - 327

EP - 680

JO - International Forum of Allergy & Rhinology

JF - International Forum of Allergy & Rhinology

SN - 2042-6976

IS - 4

ER -

International consensus statement on allergy and rhinology: Olfaction

Abstract

Keywords

Access to Document

Other files and links

JPUH Grand Rounds

Clinical Olfactory Working Group

Smell & Taste Symposium

Cite this

International consensus statement on allergy and rhinology: Olfaction

Abstract

Keywords

Access to Document

Other files and links

Activities

JPUH Grand Rounds

Clinical Olfactory Working Group

Smell & Taste Symposium

Cite this