International Consensus Statement on Rhinology and Allergy:  Rhinosinusitis

Richard Orlandi; Todd T.  Kingdom; Timothy L.  Smith; Benjamin  Bleier; Adam  DeConde; Amber  Luong; David M.  Poetker; Zachary  Soler; Kevin C.  Welch; Sarah K.  Wise; Nithin  Adappa; Jeremiah A.  Alt; Wilma Terezinha Anselmo-Lima; Claus Bachert; Fuad M.  Baroody; Pete S.  Batra; Manuel Bernal-Sprekelsen; Daniel  Beswick; Neil  Bhattacharyya; Rakesh K.  Chandra; Eugene  Chang; Alexander  Chiu; Naweed  Chowdhury; Martin J. Citardi; Noam  Cohen; David B.  Conley; John  DelGaudio; Martin Desrosiers; Richard Douglas; Jean  Anderson Eloy; Wytske J.  Fokkens; Stacey T.  Gray; David A.  Gudis; Daniel L.  Hamilos; Joseph K.  Han; Richard Harvey; Peter Hellings; Eric H. Holbrook; Claire  Hopkins; Peter  Hwang; Amin R. Javer; Rong-San  Jiang; David Kennedy; Robert  Kern; Tanya  Laidlaw; Devyani  Lal; Andrew  Lane; Heung-Man  Lee; Jivianne T.  Lee; Joshua M.  Levy; Sandra Y.  Lin; Valerie Lund; Kevin C.  McMains; Ralph  Metson; Joaquim Mullol; Robert  Naclerio; Gretchen  Oakley; Nobuyoshi  Otori; James N.  Palmer; Sanjay R.  Parikh; Desiderio  Passali; Zara  Patel; Anju  Peters; Carl Philpott; Alkis J.  Psaltis; Vijay R.  Ramakrishnan; Murugappan  Ramanathan; Hwan-Jung  Roh; Luke Rudmik; Raymond  Sacks; Rodney J.  Schlosser; Ahmad  Sedaghat; Brent Senior; Raj  Sindwani; Kristine  Smith; Kornkiat Snidvongs; Michael  Stewart; Jeffrey  Suh; Bruce K.  Tan; Justin H.  Turner; Cornelis M. van Drunen; Richard  Voegels; De-Yun Wang; Bradford A.  Woodworth; Peter-John  Wormald; Erin D.  Wright; Carol  Yan; Luo Zhang; Bing  Zhou

doi:10.1002/alr.22741

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Richard Orlandi, Todd T. Kingdom, Timothy L. Smith, Benjamin Bleier, Adam DeConde, Amber Luong, David M. Poetker, Zachary Soler, Kevin C. Welch, Sarah K. Wise, Nithin Adappa, Jeremiah A. Alt, Wilma Terezinha Anselmo-Lima, Claus Bachert, Fuad M. Baroody, Pete S. Batra, Manuel Bernal-Sprekelsen, Daniel Beswick, Neil Bhattacharyya, Rakesh K. ChandraEugene Chang, Alexander Chiu, Naweed Chowdhury, Martin J. Citardi, Noam Cohen, David B. Conley, John DelGaudio, Martin Desrosiers, Richard Douglas, Jean Anderson Eloy, Wytske J. Fokkens, Stacey T. Gray, David A. Gudis, Daniel L. Hamilos, Joseph K. Han, Richard Harvey, Peter Hellings, Eric H. Holbrook, Claire Hopkins, Peter Hwang, Amin R. Javer, Rong-San Jiang, David Kennedy, Robert Kern, Tanya Laidlaw, Devyani Lal, Andrew Lane, Heung-Man Lee, Jivianne T. Lee, Joshua M. Levy, Sandra Y. Lin, Valerie Lund, Kevin C. McMains, Ralph Metson, Joaquim Mullol, Robert Naclerio, Gretchen Oakley, Nobuyoshi Otori, James N. Palmer, Sanjay R. Parikh, Desiderio Passali, Zara Patel, Anju Peters, Carl Philpott, Alkis J. Psaltis, Vijay R. Ramakrishnan, Murugappan Ramanathan, Hwan-Jung Roh, Luke Rudmik, Raymond Sacks, Rodney J. Schlosser, Ahmad Sedaghat, Brent Senior, Raj Sindwani, Kristine Smith, Kornkiat Snidvongs, Michael Stewart, Jeffrey Suh, Bruce K. Tan, Justin H. Turner, Cornelis M. van Drunen, Richard Voegels, De-Yun Wang, Bradford A. Woodworth, Peter-John Wormald, Erin D. Wright, Carol Yan, Luo Zhang, Bing Zhou

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274 Citations (Scopus)

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Abstract

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document.

Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary.

Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided.

Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

Original language	English
Pages (from-to)	213-739
Number of pages	527
Journal	International Forum of Allergy & Rhinology
Volume	11
Issue number	3
Early online date	24 Nov 2020
DOIs	https://doi.org/10.1002/alr.22741
Publication status	Published - Mar 2021

Keywords

acute rhinosinusitis
chronic rhinosinusitis
endoscopic sinus surgery
evidence-based medicine
recurrent acute rhinosinusitis
rhinosinusitis
systematic review

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Accepted_ManuscriptAccepted author manuscript, 6.7 MB

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Orlandi, R., Kingdom, T. T., Smith, T. L., Bleier, B., DeConde, A., Luong, A., Poetker, D. M., Soler, Z., Welch, K. C., Wise, S. K., Adappa, N., Alt, J. A., Anselmo-Lima, W. T., Bachert, C., Baroody, F. M., Batra, P. S., Bernal-Sprekelsen, M., Beswick, D., Bhattacharyya, N., ... Zhou, B. (2021). International Consensus Statement on Rhinology and Allergy: Rhinosinusitis. International Forum of Allergy & Rhinology, 11(3), 213-739. https://doi.org/10.1002/alr.22741

Orlandi, Richard ; Kingdom, Todd T. ; Smith, Timothy L. ; Bleier, Benjamin ; DeConde, Adam ; Luong, Amber ; Poetker, David M. ; Soler, Zachary ; Welch, Kevin C. ; Wise, Sarah K. ; Adappa, Nithin ; Alt, Jeremiah A. ; Anselmo-Lima, Wilma Terezinha ; Bachert, Claus ; Baroody, Fuad M. ; Batra, Pete S. ; Bernal-Sprekelsen, Manuel ; Beswick, Daniel ; Bhattacharyya, Neil ; Chandra, Rakesh K. ; Chang, Eugene ; Chiu, Alexander ; Chowdhury, Naweed ; Citardi, Martin J. ; Cohen, Noam ; Conley, David B. ; DelGaudio, John ; Desrosiers, Martin ; Douglas, Richard ; Anderson Eloy, Jean ; Fokkens, Wytske J. ; Gray, Stacey T. ; Gudis, David A. ; Hamilos, Daniel L. ; Han, Joseph K. ; Harvey, Richard ; Hellings, Peter ; Holbrook, Eric H. ; Hopkins, Claire ; Hwang, Peter ; Javer, Amin R. ; Jiang, Rong-San ; Kennedy, David ; Kern, Robert ; Laidlaw, Tanya ; Lal, Devyani ; Lane, Andrew ; Lee, Heung-Man ; Lee, Jivianne T. ; Levy, Joshua M. ; Lin, Sandra Y. ; Lund, Valerie ; McMains, Kevin C. ; Metson, Ralph ; Mullol, Joaquim ; Naclerio, Robert ; Oakley, Gretchen ; Otori, Nobuyoshi ; Palmer, James N. ; Parikh, Sanjay R. ; Passali, Desiderio ; Patel, Zara ; Peters, Anju ; Philpott, Carl ; Psaltis, Alkis J. ; Ramakrishnan, Vijay R. ; Ramanathan, Murugappan ; Roh, Hwan-Jung ; Rudmik, Luke ; Sacks, Raymond ; Schlosser, Rodney J. ; Sedaghat, Ahmad ; Senior, Brent ; Sindwani, Raj ; Smith, Kristine ; Snidvongs, Kornkiat ; Stewart, Michael ; Suh, Jeffrey ; Tan, Bruce K. ; Turner, Justin H. ; van Drunen, Cornelis M. ; Voegels, Richard ; Wang, De-Yun ; Woodworth, Bradford A. ; Wormald, Peter-John ; Wright, Erin D. ; Yan, Carol ; Zhang, Luo ; Zhou, Bing . / International Consensus Statement on Rhinology and Allergy: Rhinosinusitis. In: International Forum of Allergy & Rhinology. 2021 ; Vol. 11, No. 3. pp. 213-739.

@article{760b404f61904e93b5395f6b16e02df5,

title = "International Consensus Statement on Rhinology and Allergy: Rhinosinusitis",

abstract = "Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document.Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary.Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided.Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.",

keywords = "acute rhinosinusitis, chronic rhinosinusitis, endoscopic sinus surgery, evidence-based medicine, recurrent acute rhinosinusitis, rhinosinusitis, systematic review",

author = "Richard Orlandi and Kingdom, {Todd T.} and Smith, {Timothy L.} and Benjamin Bleier and Adam DeConde and Amber Luong and Poetker, {David M.} and Zachary Soler and Welch, {Kevin C.} and Wise, {Sarah K.} and Nithin Adappa and Alt, {Jeremiah A.} and Anselmo-Lima, {Wilma Terezinha} and Claus Bachert and Baroody, {Fuad M.} and Batra, {Pete S.} and Manuel Bernal-Sprekelsen and Daniel Beswick and Neil Bhattacharyya and Chandra, {Rakesh K.} and Eugene Chang and Alexander Chiu and Naweed Chowdhury and Citardi, {Martin J.} and Noam Cohen and Conley, {David B.} and John DelGaudio and Martin Desrosiers and Richard Douglas and {Anderson Eloy}, Jean and Fokkens, {Wytske J.} and Gray, {Stacey T.} and Gudis, {David A.} and Hamilos, {Daniel L.} and Han, {Joseph K.} and Richard Harvey and Peter Hellings and Holbrook, {Eric H.} and Claire Hopkins and Peter Hwang and Javer, {Amin R.} and Rong-San Jiang and David Kennedy and Robert Kern and Tanya Laidlaw and Devyani Lal and Andrew Lane and Heung-Man Lee and Lee, {Jivianne T.} and Levy, {Joshua M.} and Lin, {Sandra Y.} and Valerie Lund and McMains, {Kevin C.} and Ralph Metson and Joaquim Mullol and Robert Naclerio and Gretchen Oakley and Nobuyoshi Otori and Palmer, {James N.} and Parikh, {Sanjay R.} and Desiderio Passali and Zara Patel and Anju Peters and Carl Philpott and Psaltis, {Alkis J.} and Ramakrishnan, {Vijay R.} and Murugappan Ramanathan and Hwan-Jung Roh and Luke Rudmik and Raymond Sacks and Schlosser, {Rodney J.} and Ahmad Sedaghat and Brent Senior and Raj Sindwani and Kristine Smith and Kornkiat Snidvongs and Michael Stewart and Jeffrey Suh and Tan, {Bruce K.} and Turner, {Justin H.} and {van Drunen}, {Cornelis M.} and Richard Voegels and De-Yun Wang and Woodworth, {Bradford A.} and Peter-John Wormald and Wright, {Erin D.} and Carol Yan and Luo Zhang and Bing Zhou",

year = "2021",

month = mar,

doi = "10.1002/alr.22741",

language = "English",

volume = "11",

pages = "213--739",

journal = "International Forum of Allergy & Rhinology",

issn = "2042-6976",

publisher = "Wiley",

number = "3",

}

Orlandi, R, Kingdom, TT, Smith, TL, Bleier, B, DeConde, A, Luong, A, Poetker, DM, Soler, Z, Welch, KC, Wise, SK, Adappa, N, Alt, JA, Anselmo-Lima, WT, Bachert, C, Baroody, FM, Batra, PS, Bernal-Sprekelsen, M, Beswick, D, Bhattacharyya, N, Chandra, RK, Chang, E, Chiu, A, Chowdhury, N, Citardi, MJ, Cohen, N, Conley, DB, DelGaudio, J, Desrosiers, M, Douglas, R, Anderson Eloy, J, Fokkens, WJ, Gray, ST, Gudis, DA, Hamilos, DL, Han, JK, Harvey, R, Hellings, P, Holbrook, EH, Hopkins, C, Hwang, P, Javer, AR, Jiang, R-S, Kennedy, D, Kern, R, Laidlaw, T, Lal, D, Lane, A, Lee, H-M, Lee, JT, Levy, JM, Lin, SY, Lund, V, McMains, KC, Metson, R, Mullol, J, Naclerio, R, Oakley, G, Otori, N, Palmer, JN, Parikh, SR, Passali, D, Patel, Z, Peters, A, Philpott, C, Psaltis, AJ, Ramakrishnan, VR, Ramanathan, M, Roh, H-J, Rudmik, L, Sacks, R, Schlosser, RJ, Sedaghat, A, Senior, B, Sindwani, R, Smith, K, Snidvongs, K, Stewart, M, Suh, J, Tan, BK, Turner, JH, van Drunen, CM, Voegels, R, Wang, D-Y, Woodworth, BA, Wormald, P-J, Wright, ED, Yan, C, Zhang, L & Zhou, B 2021, 'International Consensus Statement on Rhinology and Allergy: Rhinosinusitis', International Forum of Allergy & Rhinology, vol. 11, no. 3, pp. 213-739. https://doi.org/10.1002/alr.22741

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis. / Orlandi, Richard; Kingdom, Todd T. ; Smith, Timothy L. ; Bleier, Benjamin ; DeConde, Adam ; Luong, Amber ; Poetker, David M. ; Soler, Zachary ; Welch, Kevin C. ; Wise, Sarah K. ; Adappa, Nithin ; Alt, Jeremiah A. ; Anselmo-Lima, Wilma Terezinha; Bachert, Claus; Baroody, Fuad M. ; Batra, Pete S. ; Bernal-Sprekelsen, Manuel; Beswick, Daniel ; Bhattacharyya, Neil ; Chandra, Rakesh K. ; Chang, Eugene ; Chiu, Alexander ; Chowdhury, Naweed ; Citardi, Martin J.; Cohen, Noam ; Conley, David B. ; DelGaudio, John ; Desrosiers, Martin; Douglas, Richard; Anderson Eloy, Jean ; Fokkens, Wytske J. ; Gray, Stacey T. ; Gudis, David A. ; Hamilos, Daniel L. ; Han, Joseph K. ; Harvey, Richard; Hellings, Peter; Holbrook, Eric H.; Hopkins, Claire ; Hwang, Peter ; Javer, Amin R.; Jiang, Rong-San ; Kennedy, David; Kern, Robert ; Laidlaw, Tanya ; Lal, Devyani ; Lane, Andrew ; Lee, Heung-Man ; Lee, Jivianne T. ; Levy, Joshua M. ; Lin, Sandra Y. ; Lund, Valerie; McMains, Kevin C. ; Metson, Ralph ; Mullol, Joaquim; Naclerio, Robert ; Oakley, Gretchen ; Otori, Nobuyoshi ; Palmer, James N. ; Parikh, Sanjay R. ; Passali, Desiderio ; Patel, Zara ; Peters, Anju ; Philpott, Carl; Psaltis, Alkis J. ; Ramakrishnan, Vijay R. ; Ramanathan, Murugappan ; Roh, Hwan-Jung ; Rudmik, Luke; Sacks, Raymond ; Schlosser, Rodney J. ; Sedaghat, Ahmad ; Senior, Brent; Sindwani, Raj ; Smith, Kristine ; Snidvongs, Kornkiat; Stewart, Michael ; Suh, Jeffrey ; Tan, Bruce K. ; Turner, Justin H. ; van Drunen, Cornelis M.; Voegels, Richard ; Wang, De-Yun; Woodworth, Bradford A. ; Wormald, Peter-John ; Wright, Erin D. ; Yan, Carol ; Zhang, Luo; Zhou, Bing .

In: International Forum of Allergy & Rhinology, Vol. 11, No. 3, 03.2021, p. 213-739.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

AU - Orlandi, Richard

AU - Kingdom, Todd T.

AU - Smith, Timothy L.

AU - Bleier, Benjamin

AU - DeConde, Adam

AU - Luong, Amber

AU - Poetker, David M.

AU - Soler, Zachary

AU - Welch, Kevin C.

AU - Wise, Sarah K.

AU - Adappa, Nithin

AU - Alt, Jeremiah A.

AU - Anselmo-Lima, Wilma Terezinha

AU - Bachert, Claus

AU - Baroody, Fuad M.

AU - Batra, Pete S.

AU - Bernal-Sprekelsen, Manuel

AU - Beswick, Daniel

AU - Bhattacharyya, Neil

AU - Chandra, Rakesh K.

AU - Chang, Eugene

AU - Chiu, Alexander

AU - Chowdhury, Naweed

AU - Citardi, Martin J.

AU - Cohen, Noam

AU - Conley, David B.

AU - DelGaudio, John

AU - Desrosiers, Martin

AU - Douglas, Richard

AU - Anderson Eloy, Jean

AU - Fokkens, Wytske J.

AU - Gray, Stacey T.

AU - Gudis, David A.

AU - Hamilos, Daniel L.

AU - Han, Joseph K.

AU - Harvey, Richard

AU - Hellings, Peter

AU - Holbrook, Eric H.

AU - Hopkins, Claire

AU - Hwang, Peter

AU - Javer, Amin R.

AU - Jiang, Rong-San

AU - Kennedy, David

AU - Kern, Robert

AU - Laidlaw, Tanya

AU - Lal, Devyani

AU - Lane, Andrew

AU - Lee, Heung-Man

AU - Lee, Jivianne T.

AU - Levy, Joshua M.

AU - Lin, Sandra Y.

AU - Lund, Valerie

AU - McMains, Kevin C.

AU - Metson, Ralph

AU - Mullol, Joaquim

AU - Naclerio, Robert

AU - Oakley, Gretchen

AU - Otori, Nobuyoshi

AU - Palmer, James N.

AU - Parikh, Sanjay R.

AU - Passali, Desiderio

AU - Patel, Zara

AU - Peters, Anju

AU - Philpott, Carl

AU - Psaltis, Alkis J.

AU - Ramakrishnan, Vijay R.

AU - Ramanathan, Murugappan

AU - Roh, Hwan-Jung

AU - Rudmik, Luke

AU - Sacks, Raymond

AU - Schlosser, Rodney J.

AU - Sedaghat, Ahmad

AU - Senior, Brent

AU - Sindwani, Raj

AU - Smith, Kristine

AU - Snidvongs, Kornkiat

AU - Stewart, Michael

AU - Suh, Jeffrey

AU - Tan, Bruce K.

AU - Turner, Justin H.

AU - van Drunen, Cornelis M.

AU - Voegels, Richard

AU - Wang, De-Yun

AU - Woodworth, Bradford A.

AU - Wormald, Peter-John

AU - Wright, Erin D.

AU - Yan, Carol

AU - Zhang, Luo

AU - Zhou, Bing

PY - 2021/3

Y1 - 2021/3

N2 - Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document.Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary.Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided.Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

AB - Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document.Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary.Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided.Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

KW - acute rhinosinusitis

KW - chronic rhinosinusitis

KW - endoscopic sinus surgery

KW - evidence-based medicine

KW - recurrent acute rhinosinusitis

KW - rhinosinusitis

KW - systematic review

UR - http://www.scopus.com/inward/record.url?scp=85102586381&partnerID=8YFLogxK

U2 - 10.1002/alr.22741

DO - 10.1002/alr.22741

M3 - Review article

VL - 11

SP - 213

EP - 739

JO - International Forum of Allergy & Rhinology

JF - International Forum of Allergy & Rhinology

SN - 2042-6976

IS - 3

ER -

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

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