Interplay between cell-surface receptor and intracellular NLR-mediated immune responses

Jiorgos Kourelis

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The functional link between cell-surface receptors and intracellular NLR immune receptors is a critical aspect of plant immunity. To establish disease, successful pathogens have evolved mechanisms to suppress cell-surface immune signalling. In response, plants have adapted by evolving NLRs that recognize pathogen effectors involved in this suppression, thereby counteracting their immune-suppressing function. This ongoing co-evolutionary struggle has seemingly resulted in intertwined signalling pathways in some plant species, where NLRs form a separate signalling branch downstream of activated cell-surface receptor complexes essential for full immunity. Understanding these interconnected receptor networks could lead to novel strategies for developing durable disease resistance.

Original languageEnglish
Pages (from-to)2218-2226
Number of pages9
JournalNew Phytologist
Issue number6
Early online date22 Aug 2023
Publication statusPublished - Dec 2023


  • cell-surface immunity
  • cellular signalling
  • intracellular NLR-mediated immunity
  • phosphorylation cascade
  • plant immunity

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