Abstract
Parenteral nutrition and the absence of luminal feeding result in impaired intestinal growth and differentiation of enterocytes. Glucagon-like peptide 2 (GLP-2) and epidermal growth factor (EGF) have each been shown to have trophic effects on the intestine, and thus have the potential to benefit patients fed parenterally, such as those with intestinal failure from short bowel syndrome. We report studies aimed to determine whether there may be synergistic effects of these 2 peptides.
Original language | English |
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Pages (from-to) | 248-254 |
Number of pages | 7 |
Journal | Journal of Parenteral and Enteral Nutrition |
Volume | 29 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 2005 |
Keywords
- Adaptation, Physiological
- Animals
- Cell Division
- Disease Models, Animal
- Drug Synergism
- Epidermal Growth Factor
- Glucagon-Like Peptide 2
- Glucagon-Like Peptides
- Intestine, Small
- Male
- Organ Size
- Parenteral Nutrition
- Peptides
- Random Allocation
- Rats
- Rats, Wistar
- Short Bowel Syndrome