Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor

Paul A Kitchen, Robert A Goodlad, Anthony J FitzGerald, Nikki Mandir, Mohammed A Ghatei, Stephen R Bloom, Jorge Berlanga-Acosta, Raymond J Playford, Alastair Forbes, Julian R F Walters

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23 Citations (Scopus)

Abstract

Parenteral nutrition and the absence of luminal feeding result in impaired intestinal growth and differentiation of enterocytes. Glucagon-like peptide 2 (GLP-2) and epidermal growth factor (EGF) have each been shown to have trophic effects on the intestine, and thus have the potential to benefit patients fed parenterally, such as those with intestinal failure from short bowel syndrome. We report studies aimed to determine whether there may be synergistic effects of these 2 peptides.
Original languageEnglish
Pages (from-to)248-54
Number of pages7
JournalJournal of Parenteral and Enteral Nutrition
Volume29
Issue number4
Publication statusPublished - 2005

Keywords

  • Adaptation, Physiological
  • Animals
  • Cell Division
  • Disease Models, Animal
  • Drug Synergism
  • Epidermal Growth Factor
  • Glucagon-Like Peptide 2
  • Glucagon-Like Peptides
  • Intestine, Small
  • Male
  • Organ Size
  • Parenteral Nutrition
  • Peptides
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Short Bowel Syndrome

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