Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor

Paul A. Kitchen; Robert A. Goodlad; Anthony J. FitzGerald; Nikki Mandir; Mohammed A. Ghatei; Stephen R. Bloom; Jorge Berlanga-Acosta; Raymond J. Playford; Alastair Forbes; Julian R. F. Walters

doi:10.1177/0148607105029004248

Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor

Paul A. Kitchen, Robert A. Goodlad, Anthony J. FitzGerald, Nikki Mandir, Mohammed A. Ghatei, Stephen R. Bloom, Jorge Berlanga-Acosta, Raymond J. Playford, Alastair Forbes, Julian R. F. Walters

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Parenteral nutrition and the absence of luminal feeding result in impaired intestinal growth and differentiation of enterocytes. Glucagon-like peptide 2 (GLP-2) and epidermal growth factor (EGF) have each been shown to have trophic effects on the intestine, and thus have the potential to benefit patients fed parenterally, such as those with intestinal failure from short bowel syndrome. We report studies aimed to determine whether there may be synergistic effects of these 2 peptides.

Original language	English
Pages (from-to)	248-254
Number of pages	7
Journal	Journal of Parenteral and Enteral Nutrition
Volume	29
Issue number	4
DOIs	https://doi.org/10.1177/0148607105029004248
Publication status	Published - Jul 2005

Keywords

Adaptation, Physiological
Animals
Cell Division
Disease Models, Animal
Drug Synergism
Epidermal Growth Factor
Glucagon-Like Peptide 2
Glucagon-Like Peptides
Intestine, Small
Male
Organ Size
Parenteral Nutrition
Peptides
Random Allocation
Rats
Rats, Wistar
Short Bowel Syndrome

Access to Document

10.1177/0148607105029004248

Cite this

Kitchen, P. A., Goodlad, R. A., FitzGerald, A. J., Mandir, N., Ghatei, M. A., Bloom, S. R., Berlanga-Acosta, J., Playford, R. J., Forbes, A., & Walters, J. R. F. (2005). Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor. Journal of Parenteral and Enteral Nutrition, 29(4), 248-254. https://doi.org/10.1177/0148607105029004248

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title = "Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor",

abstract = "Parenteral nutrition and the absence of luminal feeding result in impaired intestinal growth and differentiation of enterocytes. Glucagon-like peptide 2 (GLP-2) and epidermal growth factor (EGF) have each been shown to have trophic effects on the intestine, and thus have the potential to benefit patients fed parenterally, such as those with intestinal failure from short bowel syndrome. We report studies aimed to determine whether there may be synergistic effects of these 2 peptides.",

keywords = "Adaptation, Physiological, Animals, Cell Division, Disease Models, Animal, Drug Synergism, Epidermal Growth Factor, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Intestine, Small, Male, Organ Size, Parenteral Nutrition, Peptides, Random Allocation, Rats, Rats, Wistar, Short Bowel Syndrome",

author = "Kitchen, {Paul A.} and Goodlad, {Robert A.} and FitzGerald, {Anthony J.} and Nikki Mandir and Ghatei, {Mohammed A.} and Bloom, {Stephen R.} and Jorge Berlanga-Acosta and Playford, {Raymond J.} and Alastair Forbes and Walters, {Julian R. F.}",

year = "2005",

month = jul,

doi = "10.1177/0148607105029004248",

language = "English",

volume = "29",

pages = "248--254",

journal = "Journal of Parenteral and Enteral Nutrition",

issn = "0148-6071",

publisher = "Sage Publications",

number = "4",

}

Kitchen, PA, Goodlad, RA, FitzGerald, AJ, Mandir, N, Ghatei, MA, Bloom, SR, Berlanga-Acosta, J, Playford, RJ, Forbes, A & Walters, JRF 2005, 'Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor', Journal of Parenteral and Enteral Nutrition, vol. 29, no. 4, pp. 248-254. https://doi.org/10.1177/0148607105029004248

TY - JOUR

T1 - Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor

AU - Kitchen, Paul A.

AU - Goodlad, Robert A.

AU - FitzGerald, Anthony J.

AU - Mandir, Nikki

AU - Ghatei, Mohammed A.

AU - Bloom, Stephen R.

AU - Berlanga-Acosta, Jorge

AU - Playford, Raymond J.

AU - Forbes, Alastair

AU - Walters, Julian R. F.

PY - 2005/7

Y1 - 2005/7

N2 - Parenteral nutrition and the absence of luminal feeding result in impaired intestinal growth and differentiation of enterocytes. Glucagon-like peptide 2 (GLP-2) and epidermal growth factor (EGF) have each been shown to have trophic effects on the intestine, and thus have the potential to benefit patients fed parenterally, such as those with intestinal failure from short bowel syndrome. We report studies aimed to determine whether there may be synergistic effects of these 2 peptides.

AB - Parenteral nutrition and the absence of luminal feeding result in impaired intestinal growth and differentiation of enterocytes. Glucagon-like peptide 2 (GLP-2) and epidermal growth factor (EGF) have each been shown to have trophic effects on the intestine, and thus have the potential to benefit patients fed parenterally, such as those with intestinal failure from short bowel syndrome. We report studies aimed to determine whether there may be synergistic effects of these 2 peptides.

KW - Adaptation, Physiological

KW - Animals

KW - Cell Division

KW - Disease Models, Animal

KW - Drug Synergism

KW - Epidermal Growth Factor

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Intestine, Small

KW - Male

KW - Organ Size

KW - Parenteral Nutrition

KW - Peptides

KW - Random Allocation

KW - Rats

KW - Rats, Wistar

KW - Short Bowel Syndrome

U2 - 10.1177/0148607105029004248

DO - 10.1177/0148607105029004248

M3 - Article

C2 - 15961680

VL - 29

SP - 248

EP - 254

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

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