Into the multiverse: Advances in single-cell multiomic profiling

Silvia Ogbeide, Francesca Giannese, Laura Mincarelli, Iain C. Macaulay

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Single-cell transcriptomic approaches have revolutionised the study of complex biological systems, with the routine measurement of gene expression in thousands of cells enabling construction of whole-organism cell atlases. However, the transcriptome is just one layer amongst many that coordinate to define cell type and state and, ultimately, function. In parallel with the widespread uptake of single-cell RNA-seq (scRNA-seq), there has been a rapid emergence of methods that enable multiomic profiling of individual cells, enabling parallel measurement of intercellular heterogeneity in the genome, epigenome, transcriptome, and proteomes. Linking measurements from each of these layers has the potential to reveal regulatory and functional mechanisms underlying cell behaviour in healthy development and disease.

Original languageEnglish
Pages (from-to)831-843
Number of pages13
JournalTrends in Genetics
Volume38
Issue number8
Early online date8 May 2022
DOIs
Publication statusPublished - Aug 2022

Keywords

  • epigenomics
  • genomics
  • multiomics
  • single-cell
  • transcriptomics

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