Abstract
OBJECTIVE: To investigate the intraarticular pressure (IAP) dynamics of a spectrum of joints in rheumatoid and normal subjects in order to determine whether a reperfusion event is likely to occur at these sites.
METHODS: IAP was measured in the metacarpophalangeal (MCP) (n = 8), wrist (n = 8), ankle (n = 4), and elbow joints (n = 4) of rheumatoid subjects, in addition to the MCP (n = 8), wrist (n = 6), and ankle joints (n = 1) of normal healthy controls, using the hand held portable 295-1 Intra-Compartmental Pressure Monitor System (Stryker, UK).
RESULTS: Resting IAP was positive in all rheumatoid joints, and subatmospheric or weakly atmospheric in normal subjects (p < 0.01). Exercise produced an increase in IAP in rheumatoid subjects only (p < 0.01). The addition of saline to normal joints mimicked the IAP changes seen in the rheumatoid group.
CONCLUSION: These observations suggest that increased resting IAP is a marker for chronic joint inflammation. The IAP increase seen in the rheumatoid group during exercise supports the concept of hypoxic reperfusion mediated joint injury.
Original language | English |
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Pages (from-to) | 670-673 |
Number of pages | 4 |
Journal | Annals of the Rheumatic Diseases |
Volume | 54 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 1995 |
Externally published | Yes |
Keywords
- Adult
- Aged
- Ankle Joint/physiopathology
- Arthritis, Rheumatoid/physiopathology
- Elbow Joint/physiopathology
- Exercise/physiology
- Female
- Humans
- Joints/physiopathology
- Male
- Metacarpophalangeal Joint/physiopathology
- Middle Aged
- Pressure
- Reperfusion Injury/physiopathology
- Wrist Joint/physiopathology