Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme MacLennan, Seonaidh Cotton, Sofia Papadopoulou, Martin Feelisch, Nicholas Bunce, Pitt O. Lim, David Hildick-Smith, John Horowitz, Melanie Madhani, Nicholas Boon, Dana Dawson, Juan Carlos Kaski, Michael Frenneaux, Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme MacLennanSeonaidh Cotton, Dana Dawson, Satnam Singh, Konstantin Schwarz, Baljit Jagpal, Malcolm Metcalfe, Andrew Stewart, Andrew Hannah, Noman Awsan, Paul Broadhurst, Duncan Hogg, Deepak Garg, Elaine Slattery, Tracey Davidson, Alison McDonald, Gladys McPherson, Juan-Carlo Kaski, Pitt O. Lim, Sue Brown, Sofia A. Papadopoulou, Fatima Gonzalvez, David Roy, Sami Firoozi, Richard Bogle, Elved Roberts, Jonathan Rhodes, David Hildick-Smith, Adam de Belder, Nina Cooter, Lorraine Bennett, John Horowitz, Sharmalar Rajendran, Rustem Dautov, Marilyn Black, Else Jansen, Nicholas Boon, Allan Struthers, William Toff, Henry Dargie, Chim Lang, Peter Nightingale

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107 Citations (Scopus)

Abstract

Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).
Original languageEnglish
Pages (from-to)1255-1262
Number of pages8
JournalEuropean Heart Journal
Volume35
Issue number19
Early online date17 Mar 2014
DOIs
Publication statusPublished - 14 May 2014

Keywords

  • acute myocardial infarction
  • Ischaemia-reperfusion injury
  • Cardioprotection
  • nitrite

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