Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI)

Nishat Siddiqi; Christopher Neil; Margaret Bruce; Graeme MacLennan; Seonaidh Cotton; Sofia Papadopoulou; Martin Feelisch; Nicholas Bunce; Pitt O. Lim; David Hildick-Smith; John Horowitz; Melanie Madhani; Nicholas Boon; Dana Dawson; Juan Carlos Kaski; Michael Frenneaux; Nishat Siddiqi; Christopher Neil; Margaret Bruce; Graeme MacLennan; Seonaidh Cotton; Dana Dawson; Satnam Singh; Konstantin Schwarz; Baljit Jagpal; Malcolm Metcalfe; Andrew Stewart; Andrew Hannah; Noman Awsan; Paul Broadhurst; Duncan Hogg; Deepak Garg; Elaine Slattery; Tracey Davidson; Alison McDonald; Gladys McPherson; Juan-Carlo Kaski; Pitt O. Lim; Sue Brown; Sofia A. Papadopoulou; Fatima Gonzalvez; David Roy; Sami Firoozi; Richard Bogle; Elved Roberts; Jonathan Rhodes; David Hildick-Smith; Adam de Belder; Nina Cooter; Lorraine Bennett; John Horowitz; Sharmalar Rajendran; Rustem Dautov; Marilyn Black; Else Jansen; Nicholas Boon; Allan Struthers; William Toff; Henry Dargie; Chim Lang; Peter Nightingale

doi:10.1093/eurheartj/ehu096

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI)

Nishat Siddiqi
, Christopher Neil
, Margaret Bruce
, Graeme MacLennan
, Seonaidh Cotton
, Sofia Papadopoulou
, Martin Feelisch
, Nicholas Bunce
, Pitt O. Lim
, David Hildick-Smith
, John Horowitz
, Melanie Madhani
, Nicholas Boon
, Dana Dawson
, Juan Carlos Kaski
, Michael Frenneaux
, Nishat Siddiqi
, Christopher Neil
, Margaret Bruce
, Graeme MacLennan

Seonaidh Cotton, Dana Dawson, Satnam Singh, Konstantin Schwarz, Baljit Jagpal, Malcolm Metcalfe, Andrew Stewart, Andrew Hannah, Noman Awsan, Paul Broadhurst, Duncan Hogg, Deepak Garg, Elaine Slattery, Tracey Davidson, Alison McDonald, Gladys McPherson, Juan-Carlo Kaski, Pitt O. Lim, Sue Brown, Sofia A. Papadopoulou, Fatima Gonzalvez, David Roy, Sami Firoozi, Richard Bogle, Elved Roberts, Jonathan Rhodes, David Hildick-Smith, Adam de Belder, Nina Cooter, Lorraine Bennett, John Horowitz, Sharmalar Rajendran, Rustem Dautov, Marilyn Black, Else Jansen, Nicholas Boon, Allan Struthers, William Toff, Henry Dargie, Chim Lang, Peter Nightingale

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Abstract

Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

Original language	English
Pages (from-to)	1255-1262
Number of pages	8
Journal	European Heart Journal
Volume	35
Issue number	19
Early online date	17 Mar 2014
DOIs	https://doi.org/10.1093/eurheartj/ehu096
Publication status	Published - 14 May 2014

Keywords

acute myocardial infarction
Ischaemia-reperfusion injury
Cardioprotection
nitrite

Access to Document

10.1093/eurheartj/ehu096Licence: CC BY-NC

http://dx.doi.org/10.1093/eurheartj/ehu096Licence: CC BY-NC

Cite this

Siddiqi, N., Neil, C., Bruce, M., MacLennan, G., Cotton, S., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., Siddiqi, N., Neil, C., Bruce, M., ... Nightingale, P. (2014). Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI). European Heart Journal, 35(19), 1255-1262. https://doi.org/10.1093/eurheartj/ehu096

@article{3b0e3f5e633f4e5dab9ebcd5bb72fe33,

title = "Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI)",

abstract = "Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).",

keywords = "acute myocardial infarction, Ischaemia-reperfusion injury, Cardioprotection, nitrite",

author = "Nishat Siddiqi and Christopher Neil and Margaret Bruce and Graeme MacLennan and Seonaidh Cotton and Sofia Papadopoulou and Martin Feelisch and Nicholas Bunce and Lim, \{Pitt O.\} and David Hildick-Smith and John Horowitz and Melanie Madhani and Nicholas Boon and Dana Dawson and Kaski, \{Juan Carlos\} and Michael Frenneaux and Nishat Siddiqi and Christopher Neil and Margaret Bruce and Graeme MacLennan and Seonaidh Cotton and Dana Dawson and Satnam Singh and Konstantin Schwarz and Baljit Jagpal and Malcolm Metcalfe and Andrew Stewart and Andrew Hannah and Noman Awsan and Paul Broadhurst and Duncan Hogg and Deepak Garg and Elaine Slattery and Tracey Davidson and Alison McDonald and Gladys McPherson and Juan-Carlo Kaski and Lim, \{Pitt O.\} and Sue Brown and Papadopoulou, \{Sofia A.\} and Fatima Gonzalvez and David Roy and Sami Firoozi and Richard Bogle and Elved Roberts and Jonathan Rhodes and David Hildick-Smith and \{de Belder\}, Adam and Nina Cooter and Lorraine Bennett and John Horowitz and Sharmalar Rajendran and Rustem Dautov and Marilyn Black and Else Jansen and Nicholas Boon and Allan Struthers and William Toff and Henry Dargie and Chim Lang and Peter Nightingale",

year = "2014",

month = may,

day = "14",

doi = "10.1093/eurheartj/ehu096",

language = "English",

volume = "35",

pages = "1255--1262",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

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}

Siddiqi, N, Neil, C, Bruce, M, MacLennan, G, Cotton, S, Papadopoulou, S, Feelisch, M, Bunce, N, Lim, PO, Hildick-Smith, D, Horowitz, J, Madhani, M, Boon, N, Dawson, D, Kaski, JC, Frenneaux, M, Siddiqi, N, Neil, C, Bruce, M, MacLennan, G, Cotton, S, Dawson, D, Singh, S, Schwarz, K, Jagpal, B, Metcalfe, M, Stewart, A, Hannah, A, Awsan, N, Broadhurst, P, Hogg, D, Garg, D, Slattery, E, Davidson, T, McDonald, A, McPherson, G, Kaski, J-C, Lim, PO, Brown, S, Papadopoulou, SA, Gonzalvez, F, Roy, D, Firoozi, S, Bogle, R, Roberts, E, Rhodes, J, Hildick-Smith, D, de Belder, A, Cooter, N, Bennett, L, Horowitz, J, Rajendran, S, Dautov, R, Black, M, Jansen, E, Boon, N, Struthers, A, Toff, W, Dargie, H, Lang, C & Nightingale, P 2014, 'Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI)', European Heart Journal, vol. 35, no. 19, pp. 1255-1262. https://doi.org/10.1093/eurheartj/ehu096

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T1 - Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI)

AU - Siddiqi, Nishat

AU - Neil, Christopher

AU - Bruce, Margaret

AU - MacLennan, Graeme

AU - Cotton, Seonaidh

AU - Papadopoulou, Sofia

AU - Feelisch, Martin

AU - Bunce, Nicholas

AU - Lim, Pitt O.

AU - Hildick-Smith, David

AU - Horowitz, John

AU - Madhani, Melanie

AU - Boon, Nicholas

AU - Dawson, Dana

AU - Kaski, Juan Carlos

AU - Frenneaux, Michael

AU - Siddiqi, Nishat

AU - Neil, Christopher

AU - Bruce, Margaret

AU - MacLennan, Graeme

AU - Cotton, Seonaidh

AU - Dawson, Dana

AU - Singh, Satnam

AU - Schwarz, Konstantin

AU - Jagpal, Baljit

AU - Metcalfe, Malcolm

AU - Stewart, Andrew

AU - Hannah, Andrew

AU - Awsan, Noman

AU - Broadhurst, Paul

AU - Hogg, Duncan

AU - Garg, Deepak

AU - Slattery, Elaine

AU - Davidson, Tracey

AU - McDonald, Alison

AU - McPherson, Gladys

AU - Kaski, Juan-Carlo

AU - Lim, Pitt O.

AU - Brown, Sue

AU - Papadopoulou, Sofia A.

AU - Gonzalvez, Fatima

AU - Roy, David

AU - Firoozi, Sami

AU - Bogle, Richard

AU - Roberts, Elved

AU - Rhodes, Jonathan

AU - Hildick-Smith, David

AU - de Belder, Adam

AU - Cooter, Nina

AU - Bennett, Lorraine

AU - Horowitz, John

AU - Rajendran, Sharmalar

AU - Dautov, Rustem

AU - Black, Marilyn

AU - Jansen, Else

AU - Boon, Nicholas

AU - Struthers, Allan

AU - Toff, William

AU - Dargie, Henry

AU - Lang, Chim

AU - Nightingale, Peter

PY - 2014/5/14

Y1 - 2014/5/14

N2 - Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

AB - Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this doubleblind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI).

KW - acute myocardial infarction

KW - Ischaemia-reperfusion injury

KW - Cardioprotection

KW - nitrite

U2 - 10.1093/eurheartj/ehu096

DO - 10.1093/eurheartj/ehu096

M3 - Article

SN - 0195-668X

VL - 35

SP - 1255

EP - 1262

JO - European Heart Journal

JF - European Heart Journal

IS - 19

ER -