Investigation of a unified strategy for the synthesis of anatoxin analogues: Scope and limitations

Stephen J. Roe; David L. Hughes; Pooja Aggarwal; Robert A. Stockman

doi:10.1055/s-0029-1217021

Investigation of a unified strategy for the synthesis of anatoxin analogues: Scope and limitations

Stephen J. Roe, David L. Hughes, Pooja Aggarwal, Robert A. Stockman

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Syntheses of the potent neurotoxins and biochemical probes anatoxin-a and homoanatoxin and several analogues by a combined two-directional synthesis-tandem reaction strategy are presented. Key steps include an oxidative desymmetrisation and a tandem Michael-intramolecular Mannich cyclisation.

Original language	English
Pages (from-to)	3775-3784
Journal	Synthesis-Stuttgart
Volume	2009
Issue number	22
DOIs	https://doi.org/10.1055/s-0029-1217021
Publication status	Published - 1 Nov 2009

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10.1055/s-0029-1217021

Cite this

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title = "Investigation of a unified strategy for the synthesis of anatoxin analogues: Scope and limitations",

abstract = "Syntheses of the potent neurotoxins and biochemical probes anatoxin-a and homoanatoxin and several analogues by a combined two-directional synthesis-tandem reaction strategy are presented. Key steps include an oxidative desymmetrisation and a tandem Michael-intramolecular Mannich cyclisation.",

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AU - Roe, Stephen J.

AU - Hughes, David L.

AU - Aggarwal, Pooja

AU - Stockman, Robert A.

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N2 - Syntheses of the potent neurotoxins and biochemical probes anatoxin-a and homoanatoxin and several analogues by a combined two-directional synthesis-tandem reaction strategy are presented. Key steps include an oxidative desymmetrisation and a tandem Michael-intramolecular Mannich cyclisation.

AB - Syntheses of the potent neurotoxins and biochemical probes anatoxin-a and homoanatoxin and several analogues by a combined two-directional synthesis-tandem reaction strategy are presented. Key steps include an oxidative desymmetrisation and a tandem Michael-intramolecular Mannich cyclisation.

U2 - 10.1055/s-0029-1217021

DO - 10.1055/s-0029-1217021

M3 - Article

VL - 2009

SP - 3775

EP - 3784

JO - Synthesis-Stuttgart

JF - Synthesis-Stuttgart

SN - 0039-7881

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