Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population

Alexandra V Pearce, Sheila A Fisher, Natalie J Prescott, Clive M Onnie, Reenal Pattni, Peter Green, Alastair Forbes, John Mansfield, Jeremy Sanderson, Stefan Schreiber, Cathryn M Lewis, Christopher G Mathew

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11 Citations (Scopus)

Abstract

Mutations in the DLG5 gene are associated with an increased risk of inflammatory bowel disease (IBD) in some European populations. Initial investigation of a British IBD population showed evidence of association of one of three DLG5 variants, R30Q, in a family-based collection but not in a case-control cohort. We have now examined the association of the R30Q polymorphism in a large cohort of British IBD cases, tested for interaction between the DLG5 and CARD15 genes and assessed possible association of DLG5 with clinical features of Crohn's disease (CD) and ulcerative colitis (UC).
Original languageEnglish
Pages (from-to)419-24
Number of pages6
JournalInternational Journal of Colorectal Disease
Volume22
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Case-Control Studies
  • Cohort Studies
  • Colitis, Ulcerative
  • Crohn Disease
  • England
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Inflammatory Bowel Diseases
  • Membrane Proteins
  • Phenotype
  • Polymorphism, Genetic
  • Smoking
  • Tumor Suppressor Proteins

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