Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population

Alexandra V Pearce; Sheila A Fisher; Natalie J Prescott; Clive M Onnie; Reenal Pattni; Peter Green; Alastair Forbes; John Mansfield; Jeremy Sanderson; Stefan Schreiber; Cathryn M Lewis; Christopher G Mathew

doi:10.1007/s00384-006-0151-4

Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population

Alexandra V Pearce, Sheila A Fisher, Natalie J Prescott, Clive M Onnie, Reenal Pattni, Peter Green, Alastair Forbes, John Mansfield, Jeremy Sanderson, Stefan Schreiber, Cathryn M Lewis, Christopher G Mathew

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Mutations in the DLG5 gene are associated with an increased risk of inflammatory bowel disease (IBD) in some European populations. Initial investigation of a British IBD population showed evidence of association of one of three DLG5 variants, R30Q, in a family-based collection but not in a case-control cohort. We have now examined the association of the R30Q polymorphism in a large cohort of British IBD cases, tested for interaction between the DLG5 and CARD15 genes and assessed possible association of DLG5 with clinical features of Crohn's disease (CD) and ulcerative colitis (UC).

Original language	English
Pages (from-to)	419-24
Number of pages	6
Journal	International Journal of Colorectal Disease
Volume	22
Issue number	4
DOIs	https://doi.org/10.1007/s00384-006-0151-4
Publication status	Published - Apr 2007

Keywords

Case-Control Studies
Cohort Studies
Colitis, Ulcerative
Crohn Disease
England
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Inflammatory Bowel Diseases
Membrane Proteins
Phenotype
Polymorphism, Genetic
Smoking
Tumor Suppressor Proteins

Access to Document

10.1007/s00384-006-0151-4

Cite this

Pearce, A. V., Fisher, S. A., Prescott, N. J., Onnie, C. M., Pattni, R., Green, P., Forbes, A., Mansfield, J., Sanderson, J., Schreiber, S., Lewis, C. M., & Mathew, C. G. (2007). Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population. International Journal of Colorectal Disease, 22(4), 419-24. https://doi.org/10.1007/s00384-006-0151-4

Pearce, Alexandra V ; Fisher, Sheila A ; Prescott, Natalie J ; Onnie, Clive M ; Pattni, Reenal ; Green, Peter ; Forbes, Alastair ; Mansfield, John ; Sanderson, Jeremy ; Schreiber, Stefan ; Lewis, Cathryn M ; Mathew, Christopher G. / Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population. In: International Journal of Colorectal Disease. 2007 ; Vol. 22, No. 4. pp. 419-24.

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abstract = "Mutations in the DLG5 gene are associated with an increased risk of inflammatory bowel disease (IBD) in some European populations. Initial investigation of a British IBD population showed evidence of association of one of three DLG5 variants, R30Q, in a family-based collection but not in a case-control cohort. We have now examined the association of the R30Q polymorphism in a large cohort of British IBD cases, tested for interaction between the DLG5 and CARD15 genes and assessed possible association of DLG5 with clinical features of Crohn's disease (CD) and ulcerative colitis (UC).",

keywords = "Case-Control Studies, Cohort Studies, Colitis, Ulcerative, Crohn Disease, England, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Inflammatory Bowel Diseases, Membrane Proteins, Phenotype, Polymorphism, Genetic, Smoking, Tumor Suppressor Proteins",

author = "Pearce, {Alexandra V} and Fisher, {Sheila A} and Prescott, {Natalie J} and Onnie, {Clive M} and Reenal Pattni and Peter Green and Alastair Forbes and John Mansfield and Jeremy Sanderson and Stefan Schreiber and Lewis, {Cathryn M} and Mathew, {Christopher G}",

year = "2007",

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Pearce, AV, Fisher, SA, Prescott, NJ, Onnie, CM, Pattni, R, Green, P, Forbes, A, Mansfield, J, Sanderson, J, Schreiber, S, Lewis, CM & Mathew, CG 2007, 'Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population', International Journal of Colorectal Disease, vol. 22, no. 4, pp. 419-24. https://doi.org/10.1007/s00384-006-0151-4

Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population. / Pearce, Alexandra V; Fisher, Sheila A; Prescott, Natalie J; Onnie, Clive M; Pattni, Reenal; Green, Peter; Forbes, Alastair; Mansfield, John; Sanderson, Jeremy; Schreiber, Stefan; Lewis, Cathryn M; Mathew, Christopher G.

In: International Journal of Colorectal Disease, Vol. 22, No. 4, 04.2007, p. 419-24.

Research output: Contribution to journal › Article › peer-review

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AU - Pearce, Alexandra V

AU - Fisher, Sheila A

AU - Prescott, Natalie J

AU - Onnie, Clive M

AU - Pattni, Reenal

AU - Green, Peter

AU - Forbes, Alastair

AU - Mansfield, John

AU - Sanderson, Jeremy

AU - Schreiber, Stefan

AU - Lewis, Cathryn M

AU - Mathew, Christopher G

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KW - Case-Control Studies

KW - Cohort Studies

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - England

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Inflammatory Bowel Diseases

KW - Membrane Proteins

KW - Phenotype

KW - Polymorphism, Genetic

KW - Smoking

KW - Tumor Suppressor Proteins

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