Abstract
Treatment of O-tert-butyldimethylsilyl (TBDMS) ethers of simple alcohols, carbohydrates or nucleosides with iodine monobromide in methanol or acetonitrile constitutes an effective method for their facile deprotection. The method can tolerate acid labile functionalities such as acetals, O-p-methoxybenzyl ethers, etc. as well as base labile groups such as esters and amides. An O-tert-butyldiphenylsilyl ether also survives the reaction conditions.
Original language | English |
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Pages (from-to) | 311-312 |
Number of pages | 2 |
Journal | Synlett |
Issue number | 3 |
Publication status | Published - 1999 |
Keywords
- Iodine monobromide
- TBDMS ethers