Ion-sensitive “isothermal” responsive polymers prepared in water

Johannes Pall Magnusson, Adnan Khan, George Pasparakis, Aram Omer Saeed, Wenxin Wang, Cameron Alexander

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222 Citations (Scopus)


Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by ±40 °C following addition of Hofmeister series salts. A “hybrid” block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na2SO4, at room temperature.
Original languageEnglish
Pages (from-to)10852-10853
Number of pages2
JournalJournal of the American Chemical Society
Issue number33
Publication statusPublished - 1 Aug 2008

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