Ion-sensitive “isothermal” responsive polymers prepared in water

Johannes Pall Magnusson; Adnan Khan; George Pasparakis; Aram Omer Saeed; Wenxin Wang; Cameron Alexander

doi:10.1021/ja802609r

Ion-sensitive “isothermal” responsive polymers prepared in water

Johannes Pall Magnusson, Adnan Khan, George Pasparakis, Aram Omer Saeed, Wenxin Wang, Cameron Alexander

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

230 Citations (Scopus)

Abstract

Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by ±40 °C following addition of Hofmeister series salts. A “hybrid” block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na2SO4, at room temperature.

Original language	English
Pages (from-to)	10852-10853
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	33
DOIs	https://doi.org/10.1021/ja802609r
Publication status	Published - 1 Aug 2008

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10.1021/ja802609r

Cite this

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title = "Ion-sensitive “isothermal” responsive polymers prepared in water",

abstract = "Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by ±40 °C following addition of Hofmeister series salts. A “hybrid” block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na2SO4, at room temperature.",

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AU - Magnusson, Johannes Pall

AU - Khan, Adnan

AU - Pasparakis, George

AU - Saeed, Aram Omer

AU - Wang, Wenxin

AU - Alexander, Cameron

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by ±40 °C following addition of Hofmeister series salts. A “hybrid” block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na2SO4, at room temperature.

AB - Ion-sensitive responsive polymers are prepared under fully aqueous conditions using controlled radical polymerization. Variations in comonomer content and sequence lead to temperature and salt-dependent solution behavior, with cloud-points ranging by ±40 °C following addition of Hofmeister series salts. A “hybrid” block copolymer, composed of a statistical sequence of monomers tipped with a hydrophilic block, formed stable micelle-like assemblies that exhibited burst release of an encapsulated model drug in response to addition of a kosmotrope, Na2SO4, at room temperature.

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M3 - Article

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