Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

M Feldmann, E Andreakos, C Smith, J Bondeson, S Yoshimura, S Kiriakidis, C Monaco, C Gasparini, S Sacre, A Lundberg, E Paleolog, N J Horwood, F M Brennan, B M J Foxwell

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86 Citations (Scopus)

Abstract

There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Original languageEnglish
Pages (from-to)ii13-ii18
JournalAnnals of the Rheumatic Diseases
Volume61
Issue numberSuppl 2
DOIs
Publication statusPublished - 1 Nov 2002

Keywords

  • Adenoviridae/genetics
  • Antigen Presentation
  • Arthritis, Rheumatoid/immunology
  • Cell Culture Techniques
  • Dendritic Cells/immunology
  • Genetic Vectors
  • Humans
  • I-kappa B Proteins/genetics
  • Immunity, Cellular
  • Lymphocyte Culture Test, Mixed
  • NF-kappa B/antagonists & inhibitors
  • Synovial Membrane/immunology

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