Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

M Feldmann; E Andreakos; C Smith; J Bondeson; S Yoshimura; S Kiriakidis; C Monaco; C Gasparini; S Sacre; A Lundberg; E Paleolog; N J Horwood; F M Brennan; B M J Foxwell

doi:10.1136/ard.61.suppl_2.ii13

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

M Feldmann
, E Andreakos
, C Smith
, J Bondeson
, S Yoshimura
, S Kiriakidis
, C Monaco
, C Gasparini
, S Sacre
, A Lundberg
, E Paleolog
, N J Horwood
, F M Brennan
, B M J Foxwell

Research output: Contribution to journal › Review article › peer-review

93 Citations (Scopus)

Abstract

There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Original language	English
Pages (from-to)	ii13-ii18
Journal	Annals of the Rheumatic Diseases
Volume	61
Issue number	Suppl 2
DOIs	https://doi.org/10.1136/ard.61.suppl_2.ii13
Publication status	Published - 1 Nov 2002

Keywords

Adenoviridae/genetics
Antigen Presentation
Arthritis, Rheumatoid/immunology
Cell Culture Techniques
Dendritic Cells/immunology
Genetic Vectors
Humans
I-kappa B Proteins/genetics
Immunity, Cellular
Lymphocyte Culture Test, Mixed
NF-kappa B/antagonists & inhibitors
Synovial Membrane/immunology

Access to Document

10.1136/ard.61.suppl_2.ii13

Cite this

Feldmann, M., Andreakos, E., Smith, C., Bondeson, J., Yoshimura, S., Kiriakidis, S., Monaco, C., Gasparini, C., Sacre, S., Lundberg, A., Paleolog, E., Horwood, N. J., Brennan, F. M., & Foxwell, B. M. J. (2002). Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Annals of the Rheumatic Diseases, 61(Suppl 2), ii13-ii18. https://doi.org/10.1136/ard.61.suppl_2.ii13

@article{2e8ad01c096f4f7c8eb2a7567540b3c5,

title = "Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?",

abstract = "There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.",

keywords = "Adenoviridae/genetics, Antigen Presentation, Arthritis, Rheumatoid/immunology, Cell Culture Techniques, Dendritic Cells/immunology, Genetic Vectors, Humans, I-kappa B Proteins/genetics, Immunity, Cellular, Lymphocyte Culture Test, Mixed, NF-kappa B/antagonists \& inhibitors, Synovial Membrane/immunology",

author = "M Feldmann and E Andreakos and C Smith and J Bondeson and S Yoshimura and S Kiriakidis and C Monaco and C Gasparini and S Sacre and A Lundberg and E Paleolog and Horwood, \{N J\} and Brennan, \{F M\} and Foxwell, \{B M J\}",

year = "2002",

month = nov,

day = "1",

doi = "10.1136/ard.61.suppl\_2.ii13",

language = "English",

volume = "61",

pages = "ii13--ii18",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",