Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia

A. Falodun, Qiu Sheng-Xiang, G. Parkinson, S. Gibbons

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20 Citations (Scopus)

Abstract

Jatropha gossypifolia root bark is used in ethnomedicine for the treatment of various diseases and infections. We have studied the phytochemistry and evaluated the anticancer activity of J. gossypifolia root extract. Phytochemical investigation of the root of J. gossypifolia resulted in the isolation and characterization of one new diterpenoid along with four well-known compounds. The new compound was established by 1D and 2D NMR spectra and x-ray analysis, while spectral ( 1H, 13C NMR, and ESI-MS) characteristics of the known compounds were compared with reported data. The new compound showed potent proliferation inhibitory activity against A-549 human cancer cell line.

Original languageEnglish
Pages (from-to)636-639
Number of pages4
JournalPharmaceutical Chemistry Journal
Volume45
Issue number10
Early online date10 Feb 2012
DOIs
Publication statusPublished - 2012

Keywords

  • anticancer activity
  • cytotoxicity
  • Jatropha gossypifolia
  • lathyrane diterpenes
  • root extract

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