Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia

A. Falodun; Qiu Sheng-Xiang; G. Parkinson; S. Gibbons

doi:10.1007/s11094-012-0693-4

Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia

A. Falodun, Qiu Sheng-Xiang, G. Parkinson, S. Gibbons

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Jatropha gossypifolia root bark is used in ethnomedicine for the treatment of various diseases and infections. We have studied the phytochemistry and evaluated the anticancer activity of J. gossypifolia root extract. Phytochemical investigation of the root of J. gossypifolia resulted in the isolation and characterization of one new diterpenoid along with four well-known compounds. The new compound was established by 1D and 2D NMR spectra and x-ray analysis, while spectral ( ¹H, ¹³C NMR, and ESI-MS) characteristics of the known compounds were compared with reported data. The new compound showed potent proliferation inhibitory activity against A-549 human cancer cell line.

Original language	English
Pages (from-to)	636-639
Number of pages	4
Journal	Pharmaceutical Chemistry Journal
Volume	45
Issue number	10
Early online date	10 Feb 2012
DOIs	https://doi.org/10.1007/s11094-012-0693-4
Publication status	Published - 2012

Keywords

anticancer activity
cytotoxicity
Jatropha gossypifolia
lathyrane diterpenes
root extract

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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AU - Sheng-Xiang, Qiu

AU - Parkinson, G.

AU - Gibbons, S.

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AB - Jatropha gossypifolia root bark is used in ethnomedicine for the treatment of various diseases and infections. We have studied the phytochemistry and evaluated the anticancer activity of J. gossypifolia root extract. Phytochemical investigation of the root of J. gossypifolia resulted in the isolation and characterization of one new diterpenoid along with four well-known compounds. The new compound was established by 1D and 2D NMR spectra and x-ray analysis, while spectral ( 1H, 13C NMR, and ESI-MS) characteristics of the known compounds were compared with reported data. The new compound showed potent proliferation inhibitory activity against A-549 human cancer cell line.

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KW - cytotoxicity

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KW - lathyrane diterpenes

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Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia

Abstract

Keywords

UN SDGs

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