Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli

Matthew W. Gilmour; Helen Tabor; Gehua Wang; Clifford G. Clark; Dobryan M. Tracz; Adam B. Olson; Mariola Mascarenhas; Mohamed A. Karmali; Tim Mailman; Lai King Ng

doi:10.1128/JCM.01125-07

Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli

Matthew W. Gilmour, Helen Tabor, Gehua Wang, Clifford G. Clark, Dobryan M. Tracz, Adam B. Olson, Mariola Mascarenhas, Mohamed A. Karmali, Tim Mailman, Lai King Ng

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A coinfection of O177:NM and O55:H7 Shiga toxin-producing Escherichia coli (STEC) was identified for a child with acute bloody diarrhea and hemolytic uremic syndrome by using culture and serotype-specific molecular reagents. The profile of O157-related genetic islands revealed that the O55:H7 isolate was highly similar to O157 STEC whereas the O177:NM isolate lacked several fimbrial O islands and non-locus-of-enterocyte-effacement effector determinants. However, both STEC serotypes are known to cause serious disease, and the significant repertoire of virulence determinants in both strains made it impossible to determine their individual contributions to the clinical symptoms.

Original language	English
Pages (from-to)	3771-3773
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	45
Issue number	11
DOIs	https://doi.org/10.1128/JCM.01125-07
Publication status	Published - Nov 2007

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title = "Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli",

abstract = "A coinfection of O177:NM and O55:H7 Shiga toxin-producing Escherichia coli (STEC) was identified for a child with acute bloody diarrhea and hemolytic uremic syndrome by using culture and serotype-specific molecular reagents. The profile of O157-related genetic islands revealed that the O55:H7 isolate was highly similar to O157 STEC whereas the O177:NM isolate lacked several fimbrial O islands and non-locus-of-enterocyte-effacement effector determinants. However, both STEC serotypes are known to cause serious disease, and the significant repertoire of virulence determinants in both strains made it impossible to determine their individual contributions to the clinical symptoms.",

author = "Gilmour, {Matthew W.} and Helen Tabor and Gehua Wang and Clark, {Clifford G.} and Tracz, {Dobryan M.} and Olson, {Adam B.} and Mariola Mascarenhas and Karmali, {Mohamed A.} and Tim Mailman and Ng, {Lai King}",

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AU - Gilmour, Matthew W.

AU - Tabor, Helen

AU - Wang, Gehua

AU - Clark, Clifford G.

AU - Tracz, Dobryan M.

AU - Olson, Adam B.

AU - Mascarenhas, Mariola

AU - Karmali, Mohamed A.

AU - Mailman, Tim

AU - Ng, Lai King

PY - 2007/11

Y1 - 2007/11

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AB - A coinfection of O177:NM and O55:H7 Shiga toxin-producing Escherichia coli (STEC) was identified for a child with acute bloody diarrhea and hemolytic uremic syndrome by using culture and serotype-specific molecular reagents. The profile of O157-related genetic islands revealed that the O55:H7 isolate was highly similar to O157 STEC whereas the O177:NM isolate lacked several fimbrial O islands and non-locus-of-enterocyte-effacement effector determinants. However, both STEC serotypes are known to cause serious disease, and the significant repertoire of virulence determinants in both strains made it impossible to determine their individual contributions to the clinical symptoms.

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Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli

Abstract

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