Abstract
Ivabradine specifically inhibits the I(f) current in the sinoatrial node to lower heart rate, without affecting other aspects of cardiac function. We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction.
Original language | English |
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Pages (from-to) | 807-816 |
Number of pages | 10 |
Journal | Lancet |
Volume | 372 |
Issue number | 9641 |
DOIs | |
Publication status | Published - 6 Sept 2008 |
Keywords
- Aged
- Benzazepines
- Coronary Disease
- Double-Blind Method
- Female
- Follow-Up Studies
- Heart Rate
- Hospital Mortality
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Ventricular Dysfunction, Left