Ki-67 and outcome in clinically localised prostate cancer: Analysis of conservatively treated prostate cancer patients from the trans-atlantic prostate group study

D. M. Berney, A. Gopalan, S. Kudahetti, G. Fisher, L. Ambroisine, C. S. Foster, V. Reuter, J. Eastham, H. Møller, M. W. Kattan, W. Gerald, C. Cooper, P. Scardino, J. Cuzick

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98 Citations (Scopus)

Abstract

Treatment decisions after diagnosis of clinically localised prostate cancer are difficult due to variability in tumour behaviour. We therefore examined one of the most promising biomarkers in prostate cancer, Ki-67, in a cohort of 808 patients diagnosed with prostate cancer between 1990 and 1996 and treated conservatively. Ki-67 expression was assessed immunohistochemically, in two laboratories, by two different scoring methods and the results compared with cancer-specific and overall survival. The power of the biomarker was compared with Gleason score and initial serum prostate-specific antigen (PSA). Both methods showed that Ki-67 provided additional prognostic information beyond that available from Gleason score and PSA: for the semi-quantitative method, Δχ2 (1 d.f.)=24.6 (P=0.0001), overall survival χ2=20.5 (P=0.0001), and for the quantitative method, Δχ2 (1 d.f.)=15.1 (P=0.0001), overall survival χ2=10.85 (P=0.001). Ki-67 is a powerful biomarker in localised prostate cancer and adds to a model predicting the need for radical or conservative therapy. As it is already in widespread use in routine pathology, it is confirmed as the most promising biomarker to be applied into routine practice.

Original languageEnglish
Pages (from-to)888-893
Number of pages6
JournalBritish Journal of Cancer
Volume100
Issue number6
DOIs
Publication statusPublished - 17 Mar 2009

Keywords

  • Active surveillance
  • Biomarker
  • Ki-67
  • Prostate cancer
  • Watchful waiting

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