Kinoplastid papain-like cystein peptidases

Conor R. Caffrey; Dietmar Steverding

doi:10.1016/j.molbiopara.2009.04.009

Kinoplastid papain-like cystein peptidases

Conor R. Caffrey, Dietmar Steverding

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L. To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed.

Original language	English
Pages (from-to)	12-19
Number of pages	8
Journal	Molecular and Biochemical Parasitology
Volume	167
Issue number	1
DOIs	https://doi.org/10.1016/j.molbiopara.2009.04.009
Publication status	Published - 2009

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10.1016/j.molbiopara.2009.04.009

Cite this

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title = "Kinoplastid papain-like cystein peptidases",

abstract = "Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L. To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed.",

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AU - Steverding, Dietmar

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AB - Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L. To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed.

U2 - 10.1016/j.molbiopara.2009.04.009

DO - 10.1016/j.molbiopara.2009.04.009

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SP - 12

EP - 19

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

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