Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT

M. Scobie, S.P. Bew, M.D. Threadgill

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Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.
Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number9
Publication statusPublished - 1 Jan 1994

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