Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.
|Number of pages||5|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Publication status||Published - 1 Jan 1994|