Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT

M. Scobie; S.P. Bew; M.D. Threadgill

Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT

M. Scobie
, S.P. Bew
, M.D. Threadgill

School of Global Development

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.

Original language	English
Pages (from-to)	881-885
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	9
Publication status	Published - 1 Jan 1994

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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abstract = "Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.",

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T1 - Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT

AU - Scobie, M.

AU - Bew, S.P.

AU - Threadgill, M.D.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.

AB - Quenching the anion generated from a 2(ω-carboranylalkyl)dithiane with HO at -78°C and at 0°C intoduced deuterium exclusively at C-2 of the carborane. Extension of this model reaction to a bioreductively-targetted carborane allowed the synthesis of 2-[H]- and 2-[H]-isotopomers of a nitroimidazole-carborane which is of interest in boron neutron capture therapy (BNCT) of cancer.

UR - https://www.scopus.com/pages/publications/0028124352

M3 - Article

AN - SCOPUS:0028124352

SN - 0362-4803

VL - 34

SP - 881

EP - 885

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 9

ER -

Labelled compounds of interest as antitumour agents, part 4. Deuteration and tritiation of a nitroimidazole-carborane designed for BNCT

Abstract

UN SDGs

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