Lamotrigine-induced hallucination in patient with bipolar disorder and no history of epilepsy or psychosis: A case report and literature review

Yasir Hameed, Jaap Hamelijnck

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We report a rare case of hallucinations in a patient with bipolar affective disorder BAD without any history of psychosis or epilepsy following the introduction of lamotrigine as an add-on medication to her current treatment with lithium carbonate.

The patient has been on two previous medications (quetiapine and sodium valproate) without significant improvement and only showed partial response to lithium.

Lamotrigine was introduced as an adjunctive medication with her lithium carbonate. Her dose of lithium was 800 mg once daily with satisfactory lithium levels.

She started to report complex auditory and visual hallucinations which started two days after starting lamotrigine (25 mg once daily) and increased with its dose increase to 50 mg once daily two weeks later and resolved completely with stopping it.

Hallucinations following lamotrigine treatment in non-epileptic patients is extremely rare reaction and only few similar case reports are reported in literature.

Awareness of this rare but serious side effect is important to avoid confusion with other psychotic symptoms related to mental illness and avoid unnecessary treatment.
Original languageEnglish
Article numbera714
JournalBritish Journal of Medical Practitioners
Issue number2
Publication statusPublished - 2014


  • Anticonvulsants
  • mood stabilisers
  • bipolar disorder
  • lamotrigine
  • hallucination
  • psychosis
  • side effects
  • medication
  • education
  • training
  • drug interactions

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