Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

Fiona EA McGuigan; Helen M Macdonald; Amelia Bassiti; Rosemary Farmer; Stuart Bear; Alison Stewart; Alison Black; WD Fraser; Findlay Welsh; David M Reid; Stuart H Ralston

doi:10.1359/jbmr.061016

Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

Fiona EA McGuigan, Helen M Macdonald, Amelia Bassiti, Rosemary Farmer, Stuart Bear, Alison Stewart, Alison Black, WD Fraser, Findlay Welsh, David M Reid, Stuart H Ralston

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.

Original language	English
Pages (from-to)	195-202
Number of pages	8
Journal	Journal of Bone and Mineral Research
Volume	22
Issue number	2
DOIs	https://doi.org/10.1359/jbmr.061016
Publication status	Published - Feb 2007

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10.1359/jbmr.061016

Cite this

McGuigan, Fiona EA ; Macdonald, Helen M ; Bassiti, Amelia ; Farmer, Rosemary ; Bear, Stuart ; Stewart, Alison ; Black, Alison ; Fraser, WD ; Welsh, Findlay ; Reid, David M ; Ralston, Stuart H. / Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women. In: Journal of Bone and Mineral Research. 2007 ; Vol. 22, No. 2. pp. 195-202.

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abstract = "The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.",

author = "McGuigan, {Fiona EA} and Macdonald, {Helen M} and Amelia Bassiti and Rosemary Farmer and Stuart Bear and Alison Stewart and Alison Black and WD Fraser and Findlay Welsh and Reid, {David M} and Ralston, {Stuart H}",

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Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women. / McGuigan, Fiona EA; Macdonald, Helen M; Bassiti, Amelia; Farmer, Rosemary; Bear, Stuart; Stewart, Alison; Black, Alison; Fraser, WD; Welsh, Findlay; Reid, David M; Ralston, Stuart H.

In: Journal of Bone and Mineral Research, Vol. 22, No. 2, 02.2007, p. 195-202.

Research output: Contribution to journal › Article › peer-review

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AU - Macdonald, Helen M

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AU - Bear, Stuart

AU - Stewart, Alison

AU - Black, Alison

AU - Fraser, WD

AU - Welsh, Findlay

AU - Reid, David M

AU - Ralston, Stuart H

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DO - 10.1359/jbmr.061016

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