Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

Fiona E. A. McGuigan; Helen M. Macdonald; Amelia Bassiti; Rosemary Farmer; Stuart Bear; Alison Stewart; Alison Black; William D. Fraser; Findlay Welsh; David M. Reid; Stuart H. Ralston

doi:10.1359/jbmr.061016

Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

Fiona E. A. McGuigan, Helen M. Macdonald, Amelia Bassiti, Rosemary Farmer, Stuart Bear, Alison Stewart, Alison Black, William D. Fraser, Findlay Welsh, David M. Reid, Stuart H. Ralston

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.

Original language	English
Pages (from-to)	195-202
Number of pages	8
Journal	Journal of Bone and Mineral Research
Volume	22
Issue number	2
DOIs	https://doi.org/10.1359/jbmr.061016
Publication status	Published - 1 Feb 2007

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10.1359/jbmr.061016

Cite this

McGuigan, F. E. A., Macdonald, H. M., Bassiti, A., Farmer, R., Bear, S., Stewart, A., Black, A., Fraser, W. D., Welsh, F., Reid, D. M., & Ralston, S. H. (2007). Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women. Journal of Bone and Mineral Research, 22(2), 195-202. https://doi.org/10.1359/jbmr.061016

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