Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

Fiona EA McGuigan, Helen M Macdonald, Amelia Bassiti, Rosemary Farmer, Stuart Bear, Alison Stewart, Alison Black, WD Fraser, Findlay Welsh, David M Reid, Stuart H Ralston

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17 Citations (Scopus)


The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.
Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalJournal of Bone and Mineral Research
Issue number2
Publication statusPublished - Feb 2007

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