Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

Fiona E. A. McGuigan; Helen M. Macdonald; Amelia Bassiti; Rosemary Farmer; Stuart Bear; Alison Stewart; Alison Black; William D. Fraser; Findlay Welsh; David M. Reid; Stuart H. Ralston

doi:10.1359/jbmr.061016

Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

Fiona E. A. McGuigan, Helen M. Macdonald, Amelia Bassiti, Rosemary Farmer, Stuart Bear, Alison Stewart, Alison Black, William D. Fraser, Findlay Welsh, David M. Reid, Stuart H. Ralston

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.

Original language	English
Pages (from-to)	195-202
Number of pages	8
Journal	Journal of Bone and Mineral Research
Volume	22
Issue number	2
DOIs	https://doi.org/10.1359/jbmr.061016
Publication status	Published - 1 Feb 2007

Access to Document

10.1359/jbmr.061016

Cite this

McGuigan, F. E. A., Macdonald, H. M., Bassiti, A., Farmer, R., Bear, S., Stewart, A., Black, A., Fraser, W. D., Welsh, F., Reid, D. M., & Ralston, S. H. (2007). Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women. Journal of Bone and Mineral Research, 22(2), 195-202. https://doi.org/10.1359/jbmr.061016

@article{94f98bfe5f4c4ab8b7b361842e23ed37,

title = "Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women",

abstract = "The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.",

author = "McGuigan, {Fiona E. A.} and Macdonald, {Helen M.} and Amelia Bassiti and Rosemary Farmer and Stuart Bear and Alison Stewart and Alison Black and Fraser, {William D.} and Findlay Welsh and Reid, {David M.} and Ralston, {Stuart H.}",

year = "2007",

month = feb,

day = "1",

doi = "10.1359/jbmr.061016",

language = "English",

volume = "22",

pages = "195--202",

journal = "Journal of Bone and Mineral Research",

issn = "1523-4681",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - Large scale population-based study shows no association between common polymorphisms of the TGFBI gene and BMD in women

AU - McGuigan, Fiona E. A.

AU - Macdonald, Helen M.

AU - Bassiti, Amelia

AU - Farmer, Rosemary

AU - Bear, Stuart

AU - Stewart, Alison

AU - Black, Alison

AU - Fraser, William D.

AU - Welsh, Findlay

AU - Reid, David M.

AU - Ralston, Stuart H.

PY - 2007/2/1

Y1 - 2007/2/1

N2 - The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.

AB - The TGFB1 gene is a strong functional candidate for regulating genetic susceptibility to osteoporosis. We studied five common polymorphisms of TGFB1 in relation to osteoporosis-related phenotypes in a population-based cohort of 2975 British women, but found no significant association with bone mass, bone loss, bone markers, or fracture.

U2 - 10.1359/jbmr.061016

DO - 10.1359/jbmr.061016

M3 - Article

SN - 1523-4681

VL - 22

SP - 195

EP - 202

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 2

ER -