Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women

Helen M Macdonald; Fiona E McGuigan; Alison Stewart; Alison J Black; WD Fraser; Stuart Ralston; David M Reid

doi:10.1359/JBMR.050906

Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women

Helen M Macdonald, Fiona E McGuigan, Alison Stewart, Alison J Black, WD Fraser, Stuart Ralston, David M Reid

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Abstract

The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.

Original language	English
Pages (from-to)	151-162
Number of pages	12
Journal	Journal of Bone and Mineral Research
Volume	21
Issue number	1
DOIs	https://doi.org/10.1359/JBMR.050906
Publication status	Published - Jan 2006

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10.1359/JBMR.050906

Cite this

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title = "Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women",

abstract = "The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.",

author = "Macdonald, {Helen M} and McGuigan, {Fiona E} and Alison Stewart and Black, {Alison J} and WD Fraser and Stuart Ralston and Reid, {David M}",

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AU - Macdonald, Helen M

AU - McGuigan, Fiona E

AU - Stewart, Alison

AU - Black, Alison J

AU - Fraser, WD

AU - Ralston, Stuart

AU - Reid, David M

PY - 2006/1

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N2 - The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.

AB - The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.

U2 - 10.1359/JBMR.050906

DO - 10.1359/JBMR.050906

M3 - Article

VL - 21

SP - 151

EP - 162

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

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