Lazarus1, a DUF300 protein, contributes to programmed cell death associated with Arabidopsis acd11 and the hypersensitive response

Frederikke G. Malinovsky, Peter Brodersen, Berthe Katrine Fiil, Lea Vig McKinney, Stephan Thorgrimsen, Martina Beck, H. Bjørn Nielsen, Stefano Pietra, Cyril Zipfel, Silke Robatzek, Morten Petersen, Daniel Hofius, John Mundy

Research output: Contribution to journalArticlepeer-review


Programmed cell death (PCD) is a necessary part of the life of multi-cellular organisms. A type of plant PCD is the defensive hypersensitive response (HR) elicited via recognition of a pathogen by host resistance (R) proteins. The lethal, recessive accelerated cell death 11 (acd11) mutant exhibits HR-like accelerated cell death, and cell death execution in acd11 shares genetic requirements for HR execution triggered by one subclass of R proteins.
Original languageEnglish
Article numbere12586
JournalPLoS One
Issue number9
Publication statusPublished - 7 Sep 2010


  • Apoptosis
  • Apoptosis Regulatory Proteins
  • Arabidopsis
  • Arabidopsis Proteins
  • Cell Membrane
  • Cytosol
  • Host-Pathogen Interactions
  • Membrane Transport Proteins
  • Plant Diseases
  • Protein Structure, Tertiary
  • Protein Transport
  • Pseudomonas syringae

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