Lazarus1, a DUF300 protein, contributes to programmed cell death associated with Arabidopsis acd11 and the hypersensitive response

Frederikke G Malinovsky, Peter Brodersen, Berthe Katrine Fiil, Lea Vig McKinney, Stephan Thorgrimsen, Martina Beck, H Bjørn Nielsen, Stefano Pietra, Cyril Zipfel, Silke Robatzek, Morten Petersen, Daniel Hofius, John Mundy

Research output: Contribution to journalArticlepeer-review


Programmed cell death (PCD) is a necessary part of the life of multi-cellular organisms. A type of plant PCD is the defensive hypersensitive response (HR) elicited via recognition of a pathogen by host resistance (R) proteins. The lethal, recessive accelerated cell death 11 (acd11) mutant exhibits HR-like accelerated cell death, and cell death execution in acd11 shares genetic requirements for HR execution triggered by one subclass of R proteins.
Original languageEnglish
Article numbere12586
JournalPLoS One
Issue number9
Publication statusPublished - 2010


  • Apoptosis
  • Apoptosis Regulatory Proteins
  • Arabidopsis
  • Arabidopsis Proteins
  • Cell Membrane
  • Cytosol
  • Host-Pathogen Interactions
  • Membrane Transport Proteins
  • Plant Diseases
  • Protein Structure, Tertiary
  • Protein Transport
  • Pseudomonas syringae

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