Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus

Christian Peiser, Jochen Springer, David A. Groneberg, Gerard P. McGregor, Axel Fischer, Rudolf E. Lang

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Recent studies suggest that in addition to adipocytes the chief cells of the gastric fundic mucosa are a site of leptin production. In order to assess the possible role of vagal afferent neurons in transmitting leptin signals from the stomach to the brain, leptin receptor (OB-R) expression was investigated in rat nodose ganglion cells and their projection to the stomach determined by retrograde tracing. Reverse transcription-polymerase chain reaction combined with laser-assisted cell picking revealed that large and small diameter neurons express both the long (OB-Rb) and short (OB-Ra) splice variants of the OB-R. OB-R like immunoreactivity was detected in the perikarya of approximately 8% of nodose ganglion neurons. Tracing studies revealed that a significant proportion (15%) of the immunopositive neurons projected to the gastric fundus. These findings suggest that leptin may use a neural route to relay its message from peripheral sites of leptin synthesis such as the gastric fundus to the brain.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - 1 Mar 2002

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