Lessons in effector and NLR biology of plant-microbe systems

Aleksandra Białas, Erin K. Zess, Juan Carlos De la Concepcion, Marina Franceschetti, Helen G. Pennington, Kentaro Yoshida, Jessica L. Upson, Emilie Chanclud, Chih-Hang Wu, Thorsten Langner, Abbas Maqbool, Freya A. Varden, Lida Derevnina, Khaoula Belhaj, Koki Fujisaki, Hiromasa Saitoh, Ryohei Terauchi, Mark J. Banfield, Sophien Kamoun

Research output: Contribution to journalReview articlepeer-review

60 Citations (SciVal)

Abstract

A diversity of plant-associated organisms secrete effectors-proteins and metabolites that modulate plant physiology to favor host infection and colonization. However, effectors can also activate plant immune receptors, notably nucleotide-binding domain and leucine-rich repeat region (NLR)-containing proteins, enabling plants to fight off invading organisms. This interplay between effectors, their host targets, and the matching immune receptors is shaped by intricate molecular mechanisms and exceptionally dynamic coevolution. In this article, we focus on three effectors, AVR-Pik, AVR-Pia, and AVR-Pii, from the rice blast fungus Magnaporthe oryzae (syn. Pyricularia oryzae), and their corresponding rice NLR immune receptors, Pik, Pia, and Pii, to highlight general concepts of plant-microbe interactions. We draw 12 lessons in effector and NLR biology that have emerged from studying these three little effectors and are broadly applicable to other plant-microbe systems.

Original languageEnglish
Pages (from-to)34-45
Number of pages12
JournalMolecular Plant-Microbe Interactions
Volume31
Issue number1
Early online date16 Nov 2017
DOIs
Publication statusPublished - 18 Dec 2017

Keywords

  • Amino Acid Sequence
  • Biological Evolution
  • Genetic Variation
  • Host-Pathogen Interactions
  • NLR Proteins/chemistry
  • Plants/immunology
  • Selection, Genetic

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