Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction

Deanne Hayward; Zoë R. Goddard; Marco M. D. Cominetti; Mark Searcey; Andrew M. Beekman

doi:10.1039/D4CC01249F

Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction

Deanne Hayward, Zoë R. Goddard, Marco M. D. Cominetti, Mark Searcey, Andrew M. Beekman

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Abstract

Inhibiting the PD-1/PD-L1 protein–protein interaction is a key immunotherapy for cancer. Antibodies dominate the clinical space but are costly, with limited applicability and immune side effects. We developed a photo-controlled azobenzene peptide that selectively inhibits the PD-1/PD-L1 interaction when in the cis isomer only. Activity is demonstrated in in vitro and cellular assays.

Original language	English
Pages (from-to)	8228-8231
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	63
Early online date	9 Jul 2024
DOIs	https://doi.org/10.1039/D4CC01249F
Publication status	Published - 14 Aug 2024

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10.1039/D4CC01249FLicence: CC BY

Hayward_etal_2024_ChemComm_d4cc01249fFinal published version, 934 KBLicence: CC BY

Cite this

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title = "Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction",

abstract = "Inhibiting the PD-1/PD-L1 protein–protein interaction is a key immunotherapy for cancer. Antibodies dominate the clinical space but are costly, with limited applicability and immune side effects. We developed a photo-controlled azobenzene peptide that selectively inhibits the PD-1/PD-L1 interaction when in the cis isomer only. Activity is demonstrated in in vitro and cellular assays.",

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note = "Funding information: The authors acknowledge support from Big C Cancer Charity (19-13R) and the Royal Society (RGS\R1\201008). Mass spectrometry was supported by BBSRC (BB/T017708/1).",

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AU - Beekman, Andrew M.

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Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction

Abstract

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New high resolution mass spectrometry facilities for macromolecules and metabolites at the University of East Anglia

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Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction

Abstract

UN SDGs

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Projects

New high resolution mass spectrometry facilities for macromolecules and metabolites at the University of East Anglia

Cite this