Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas

Andoni P Toms, Lawrence M White, Rita Kandel, Robert R Bleakney, Michael Noseworthy, Lee Shepstone, Martin E Blackstein, Jay Wunder

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Single slice dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) appears to provide perfusion data about sarcomas in vivo that correlate with tumor necrosis on equivalent pathological sections. However, sarcomas are heterogeneous and therefore single slice DCE-MRI may not correlate with total tumor necrosis.
Original languageEnglish
Pages (from-to)512-20
Number of pages9
JournalActa Radiologica
Issue number5
Publication statusPublished - Jun 2009


  • Adolescent
  • Adult
  • Bone Neoplasms
  • Capillary Permeability
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Humans
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Necrosis
  • Sarcoma
  • Young Adult

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