Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas

Andoni P Toms; Lawrence M White; Rita Kandel; Robert R Bleakney; Michael Noseworthy; Lee Shepstone; Martin E Blackstein; Jay Wunder

doi:10.1080/02841850902922761

Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas

Andoni P Toms
, Lawrence M White
, Rita Kandel
, Robert R Bleakney
, Michael Noseworthy
, Lee Shepstone
, Martin E Blackstein
, Jay Wunder

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Single slice dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) appears to provide perfusion data about sarcomas in vivo that correlate with tumor necrosis on equivalent pathological sections. However, sarcomas are heterogeneous and therefore single slice DCE-MRI may not correlate with total tumor necrosis.

Original language	English
Pages (from-to)	512-20
Number of pages	9
Journal	Acta Radiologica
Volume	50
Issue number	5
DOIs	https://doi.org/10.1080/02841850902922761
Publication status	Published - Jun 2009

Keywords

Adolescent
Adult
Bone Neoplasms
Capillary Permeability
Contrast Media
Female
Gadolinium DTPA
Humans
Image Enhancement
Image Processing, Computer-Assisted
Linear Models
Magnetic Resonance Imaging
Male
Middle Aged
Necrosis
Sarcoma
Young Adult

Access to Document

10.1080/02841850902922761

Cite this

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title = "Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas",

abstract = "Single slice dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) appears to provide perfusion data about sarcomas in vivo that correlate with tumor necrosis on equivalent pathological sections. However, sarcomas are heterogeneous and therefore single slice DCE-MRI may not correlate with total tumor necrosis.",

keywords = "Adolescent, Adult, Bone Neoplasms, Capillary Permeability, Contrast Media, Female, Gadolinium DTPA, Humans, Image Enhancement, Image Processing, Computer-Assisted, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Necrosis, Sarcoma, Young Adult",

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T1 - Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas

AU - Toms, Andoni P

AU - White, Lawrence M

AU - Kandel, Rita

AU - Bleakney, Robert R

AU - Noseworthy, Michael

AU - Shepstone, Lee

AU - Blackstein, Martin E

AU - Wunder, Jay

PY - 2009/6

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N2 - Single slice dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) appears to provide perfusion data about sarcomas in vivo that correlate with tumor necrosis on equivalent pathological sections. However, sarcomas are heterogeneous and therefore single slice DCE-MRI may not correlate with total tumor necrosis.

AB - Single slice dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) appears to provide perfusion data about sarcomas in vivo that correlate with tumor necrosis on equivalent pathological sections. However, sarcomas are heterogeneous and therefore single slice DCE-MRI may not correlate with total tumor necrosis.

KW - Adolescent

KW - Adult

KW - Bone Neoplasms

KW - Capillary Permeability

KW - Contrast Media

KW - Female

KW - Gadolinium DTPA

KW - Humans

KW - Image Enhancement

KW - Image Processing, Computer-Assisted

KW - Linear Models

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Necrosis

KW - Sarcoma

KW - Young Adult

U2 - 10.1080/02841850902922761

DO - 10.1080/02841850902922761

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VL - 50

SP - 512

EP - 520

JO - Acta Radiologica

JF - Acta Radiologica

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