Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients

Robert L R Hill, Angela M Kearns, James Nash, Sarah E North, Rachel Pike, Timothy Newson, Neil Woodford, Richard Calver, David M Livermore

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To describe the emergence of linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA) of sequence type (ST)36 lineage in two paediatric patients with cystic fibrosis, after long-term low-dose linezolid treatment.
Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue number3
Publication statusPublished - Mar 2010


  • Acetamides
  • Adolescent
  • Anti-Bacterial Agents
  • Bacterial Typing Techniques
  • Bacteriophage Typing
  • Child
  • Cystic Fibrosis
  • DNA Fingerprinting
  • Drug Resistance, Bacterial
  • Genes, rRNA
  • Great Britain
  • Humans
  • Male
  • Methicillin-Resistant Staphylococcus aureus
  • Microbial Sensitivity Tests
  • Mutation
  • Oxazolidinones
  • Polymorphism, Restriction Fragment Length
  • Pseudomonas aeruginosa
  • RNA, Bacterial
  • RNA, Ribosomal, 23S
  • Sputum
  • Staphylococcal Infections

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