Lipid rafts: Microenvironments for integrin-growth factor interactions in neural development

L. Decker, W. Baron, C. Ffrench-Constant

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The development of a complex multicellular organ such as the nervous system requires precise regulation of cell migration, proliferation and survival. This regulation in turn requires the integration of long-range signals, such as growth factors, with short-range cues that define the precise location and cellular neighbours for any given cell. This short review examines one integrative mechanism, integrin-growth factor receptor interactions, and explores the role of lipid rafts in the molecular mechanisms that underlie the receptor interactions.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalBiochemical Society Transactions
Volume32
Issue number3
DOIs
Publication statusPublished - 1 Jun 2004

Keywords

  • Apoptosis
  • Laminin
  • Oligodendrocyte
  • Platelet-derived growth factor (PDGF)

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