Abstract
Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD.
Original language | English |
---|---|
Pages (from-to) | 202-209 |
Number of pages | 8 |
Journal | Circulation: Cardiovascular Genetics |
Volume | 5 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Apr 2012 |
Keywords
- Adult
- Cardiovascular Diseases
- Female
- Follow-Up Studies
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Prospective Studies
- Registries
- Risk Factors
- Young Adult