Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

Anika A M Vaarhorst, Yingchang Lu, Bastiaan T Heijmans, Martijn E T Dollé, Stefan Böhringer, Hein Putter, Sandra Imholz, Audrey H H Merry, Marleen M van Greevenbroek, J Wouter Jukema, Anton P M Gorgels, Piet A van den Brandt, Michael Müller, Leo J Schouten, Edith J M Feskens, Jolanda M A Boer, P Eline Slagboom

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Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD.
Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalCirculation: Cardiovascular Genetics
Issue number2
Publication statusPublished - 1 Apr 2012


  • Adult
  • Cardiovascular Diseases
  • Female
  • Follow-Up Studies
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • Registries
  • Risk Factors
  • Young Adult

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