Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

Anika A M Vaarhorst; Yingchang Lu; Bastiaan T Heijmans; Martijn E T Dollé; Stefan Böhringer; Hein Putter; Sandra Imholz; Audrey H H Merry; Marleen M van Greevenbroek; J Wouter Jukema; Anton P M Gorgels; Piet A van den Brandt; Michael Müller; Leo J Schouten; Edith J M Feskens; Jolanda M A Boer; P Eline Slagboom

doi:10.1161/CIRCGENETICS.111.960708

Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

Anika A M Vaarhorst
, Yingchang Lu
, Bastiaan T Heijmans
, Martijn E T Dollé
, Stefan Böhringer
, Hein Putter
, Sandra Imholz
, Audrey H H Merry
, Marleen M van Greevenbroek
, J Wouter Jukema
, Anton P M Gorgels
, Piet A van den Brandt
, Michael Müller
, Leo J Schouten
, Edith J M Feskens
, Jolanda M A Boer
, P Eline Slagboom

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD.

Original language	English
Pages (from-to)	202-209
Number of pages	8
Journal	Circulation: Cardiovascular Genetics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1161/CIRCGENETICS.111.960708
Publication status	Published - 1 Apr 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Cardiovascular Diseases
Female
Follow-Up Studies
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Prospective Studies
Registries
Risk Factors
Young Adult

Access to Document

10.1161/CIRCGENETICS.111.960708

Cite this

Vaarhorst, A. A. M., Lu, Y., Heijmans, B. T., Dollé, M. E. T., Böhringer, S., Putter, H., Imholz, S., Merry, A. H. H., van Greevenbroek, M. M., Jukema, J. W., Gorgels, A. P. M., van den Brandt, P. A., Müller, M., Schouten, L. J., Feskens, E. J. M., Boer, J. M. A., & Slagboom, P. E. (2012). Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study. Circulation: Cardiovascular Genetics, 5(2), 202-209. https://doi.org/10.1161/CIRCGENETICS.111.960708

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abstract = "Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD.",

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Vaarhorst, AAM, Lu, Y, Heijmans, BT, Dollé, MET, Böhringer, S, Putter, H, Imholz, S, Merry, AHH, van Greevenbroek, MM, Jukema, JW, Gorgels, APM, van den Brandt, PA, Müller, M, Schouten, LJ, Feskens, EJM, Boer, JMA & Slagboom, PE 2012, 'Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study', Circulation: Cardiovascular Genetics, vol. 5, no. 2, pp. 202-209. https://doi.org/10.1161/CIRCGENETICS.111.960708

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AU - Vaarhorst, Anika A M

AU - Lu, Yingchang

AU - Heijmans, Bastiaan T

AU - Dollé, Martijn E T

AU - Böhringer, Stefan

AU - Putter, Hein

AU - Imholz, Sandra

AU - Merry, Audrey H H

AU - van Greevenbroek, Marleen M

AU - Jukema, J Wouter

AU - Gorgels, Anton P M

AU - van den Brandt, Piet A

AU - Müller, Michael

AU - Schouten, Leo J

AU - Feskens, Edith J M

AU - Boer, Jolanda M A

AU - Slagboom, P Eline

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KW - Follow-Up Studies

KW - Genome-Wide Association Study

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KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Registries

KW - Risk Factors

KW - Young Adult

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