Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

R Kiesslich, C A Duckworth, D Moussata, A Gloeckner, L G Lim, M Goetz, D M Pritchard, P R Galle, M F Neurath, A J M Watson

Research output: Contribution to journalArticlepeer-review

295 Citations (Scopus)


Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD.
Original languageEnglish
Pages (from-to)1146-1153
Number of pages8
Issue number8
Publication statusPublished - Aug 2012


  • Adult
  • Disease Progression
  • Endoscopy, Gastrointestinal
  • Female
  • Fluorescein
  • Fluorescent Dyes
  • Humans
  • Inflammatory Bowel Diseases
  • Intestinal Mucosa
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Pilot Projects
  • Predictive Value of Tests
  • Prognosis
  • Prospective Studies
  • Recurrence

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