Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

R Kiesslich; C A Duckworth; D Moussata; A Gloeckner; L G Lim; M Goetz; D M Pritchard; P R Galle; M F Neurath; A J M Watson

doi:10.1136/gutjnl-2011-300695

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

R Kiesslich, C A Duckworth, D Moussata, A Gloeckner, L G Lim, M Goetz, D M Pritchard, P R Galle, M F Neurath, A J M Watson

Research output: Contribution to journal › Article › peer-review

306 Citations (Scopus)

Abstract

Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD.

Original language	English
Pages (from-to)	1146-1153
Number of pages	8
Journal	Gut
Volume	61
Issue number	8
DOIs	https://doi.org/10.1136/gutjnl-2011-300695
Publication status	Published - Aug 2012

Keywords

Adult
Disease Progression
Endoscopy, Gastrointestinal
Female
Fluorescein
Fluorescent Dyes
Humans
Inflammatory Bowel Diseases
Intestinal Mucosa
Male
Microscopy, Confocal
Middle Aged
Pilot Projects
Predictive Value of Tests
Prognosis
Prospective Studies
Recurrence

Access to Document

10.1136/gutjnl-2011-300695

Cite this

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title = "Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease",

abstract = "Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD.",

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AU - Kiesslich, R

AU - Duckworth, C A

AU - Moussata, D

AU - Gloeckner, A

AU - Lim, L G

AU - Goetz, M

AU - Pritchard, D M

AU - Galle, P R

AU - Neurath, M F

AU - Watson, A J M

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KW - Disease Progression

KW - Endoscopy, Gastrointestinal

KW - Female

KW - Fluorescein

KW - Fluorescent Dyes

KW - Humans

KW - Inflammatory Bowel Diseases

KW - Intestinal Mucosa

KW - Male

KW - Microscopy, Confocal

KW - Middle Aged

KW - Pilot Projects

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Recurrence

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DO - 10.1136/gutjnl-2011-300695

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VL - 61

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JO - Gut

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