Localized intracellular pH measurement using a ratiometric photoinduced electron-transfer-based nanosensor

María J. Marin, Francisco Galindo, Paul Thomas, David A. Russell

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69 Citations (Scopus)

Abstract

Intracellular analysis: Changes in the concentration of hydrogen ions can lead to cellular dysfunction. Thus, quantification of the intracellular pH in localized compartments (see A and B) is important. A pH nanosensor based on photoinduced electron transfer is described that targets acidic organelles. A combination of confocal fluorescence microscopy and spectroscopy is used for localized pH measurements within living cells.
Original languageEnglish
Pages (from-to)9657-9661
Number of pages5
JournalAngewandte Chemie-International Edition
Volume51
Issue number38
DOIs
Publication statusPublished - 2012

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