Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: A randomized, double-blind, placebo controlled study

Elizabeth Brink, Veronique Coxam, Simon Robins, Kristiina Wahala, Aedin Cassidy, Francesco Branca, PHYTOS Investigators

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)


Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to hormone replacement therapy for preventing bone loss during the menopausal transition.
Original languageEnglish
Pages (from-to)761-770
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Issue number3
Publication statusPublished - Mar 2008


  • Absorptiometry, Photon
  • Bone Density
  • Bone and Bones
  • Calcium
  • Consumer Product Safety
  • Double-Blind Method
  • Female
  • Food, Fortified
  • Humans
  • Isoflavones
  • Middle Aged
  • Osteoporosis, Postmenopausal
  • Parathyroid Hormone
  • Peptide Fragments
  • Postmenopause
  • Procollagen
  • Soybeans
  • Vitamin D

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