Longitudinal changes in primary progressive aphasias: Differences in cognitive and dementia staging measures

S. Hsieh; J. R. Hodges; C. E. Leyton; E. Mioshi

doi:10.1159/000342347

Longitudinal changes in primary progressive aphasias: Differences in cognitive and dementia staging measures

S. Hsieh, J. R. Hodges, C. E. Leyton, E. Mioshi

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

BACKGROUND/AIMS: The longitudinal course of three primary progressive aphasia (PPA) variants was examined using Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Frontotemporal dementia Rating Scale (FRS).

METHODS: Cases with two assessments on the ACE-R and FRS were selected. A total of 220 assessments were obtained on 55 patients: 17 Alzheimer's disease (AD) and 38 PPA [17 semantic variant (svPPA), 12 non-fluent/agrammatic (naPPA) and 9 logopenic variant (lvPPA) cases].

RESULTS: The annualized rate of change was greater in all PPA variants in comparison with the AD group on the ACE-R whereas only the svPPA and naPPA groups differed from AD on the FRS.

CONCLUSIONS: The longitudinal profile differs across PPA syndromes on cognitive and functional measures. Findings have theoretical implications and are relevant to the care of patients with dementia.

Original language	English
Pages (from-to)	135-141
Number of pages	7
Journal	Dementia and Geriatric Cognitive Disorders
Volume	34
Issue number	2
DOIs	https://doi.org/10.1159/000342347
Publication status	Published - 2012

Keywords

Aged
Alzheimer Disease/diagnosis
Aphasia, Primary Progressive/diagnosis
Disease Progression
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Primary Progressive Nonfluent Aphasia/diagnosis

Access to Document

10.1159/000342347

Cite this

@article{15ee9b9e0c46445780fbc0fb1cb3e3b5,

title = "Longitudinal changes in primary progressive aphasias: Differences in cognitive and dementia staging measures",

abstract = "BACKGROUND/AIMS: The longitudinal course of three primary progressive aphasia (PPA) variants was examined using Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Frontotemporal dementia Rating Scale (FRS).METHODS: Cases with two assessments on the ACE-R and FRS were selected. A total of 220 assessments were obtained on 55 patients: 17 Alzheimer's disease (AD) and 38 PPA [17 semantic variant (svPPA), 12 non-fluent/agrammatic (naPPA) and 9 logopenic variant (lvPPA) cases].RESULTS: The annualized rate of change was greater in all PPA variants in comparison with the AD group on the ACE-R whereas only the svPPA and naPPA groups differed from AD on the FRS.CONCLUSIONS: The longitudinal profile differs across PPA syndromes on cognitive and functional measures. Findings have theoretical implications and are relevant to the care of patients with dementia.",

keywords = "Aged, Alzheimer Disease/diagnosis, Aphasia, Primary Progressive/diagnosis, Disease Progression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Primary Progressive Nonfluent Aphasia/diagnosis",

author = "S. Hsieh and Hodges, {J. R.} and Leyton, {C. E.} and E. Mioshi",

year = "2012",

doi = "10.1159/000342347",

language = "English",

volume = "34",

pages = "135--141",

journal = "Dementia and Geriatric Cognitive Disorders",

issn = "1420-8008",

publisher = "S. Karger AG",

number = "2",

}

TY - JOUR

T1 - Longitudinal changes in primary progressive aphasias: Differences in cognitive and dementia staging measures

AU - Hsieh, S.

AU - Hodges, J. R.

AU - Leyton, C. E.

AU - Mioshi, E.

PY - 2012

Y1 - 2012

N2 - BACKGROUND/AIMS: The longitudinal course of three primary progressive aphasia (PPA) variants was examined using Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Frontotemporal dementia Rating Scale (FRS).METHODS: Cases with two assessments on the ACE-R and FRS were selected. A total of 220 assessments were obtained on 55 patients: 17 Alzheimer's disease (AD) and 38 PPA [17 semantic variant (svPPA), 12 non-fluent/agrammatic (naPPA) and 9 logopenic variant (lvPPA) cases].RESULTS: The annualized rate of change was greater in all PPA variants in comparison with the AD group on the ACE-R whereas only the svPPA and naPPA groups differed from AD on the FRS.CONCLUSIONS: The longitudinal profile differs across PPA syndromes on cognitive and functional measures. Findings have theoretical implications and are relevant to the care of patients with dementia.

AB - BACKGROUND/AIMS: The longitudinal course of three primary progressive aphasia (PPA) variants was examined using Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Frontotemporal dementia Rating Scale (FRS).METHODS: Cases with two assessments on the ACE-R and FRS were selected. A total of 220 assessments were obtained on 55 patients: 17 Alzheimer's disease (AD) and 38 PPA [17 semantic variant (svPPA), 12 non-fluent/agrammatic (naPPA) and 9 logopenic variant (lvPPA) cases].RESULTS: The annualized rate of change was greater in all PPA variants in comparison with the AD group on the ACE-R whereas only the svPPA and naPPA groups differed from AD on the FRS.CONCLUSIONS: The longitudinal profile differs across PPA syndromes on cognitive and functional measures. Findings have theoretical implications and are relevant to the care of patients with dementia.

KW - Aged

KW - Alzheimer Disease/diagnosis

KW - Aphasia, Primary Progressive/diagnosis

KW - Disease Progression

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Neuropsychological Tests

KW - Primary Progressive Nonfluent Aphasia/diagnosis

U2 - 10.1159/000342347

DO - 10.1159/000342347

M3 - Article

C2 - 23006977

VL - 34

SP - 135

EP - 141

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 2

ER -