Longitudinal changes in primary progressive aphasias: Differences in cognitive and dementia staging measures

S. Hsieh, J. R. Hodges, C. E. Leyton, E. Mioshi

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


BACKGROUND/AIMS: The longitudinal course of three primary progressive aphasia (PPA) variants was examined using Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Frontotemporal dementia Rating Scale (FRS).

METHODS: Cases with two assessments on the ACE-R and FRS were selected. A total of 220 assessments were obtained on 55 patients: 17 Alzheimer's disease (AD) and 38 PPA [17 semantic variant (svPPA), 12 non-fluent/agrammatic (naPPA) and 9 logopenic variant (lvPPA) cases].

RESULTS: The annualized rate of change was greater in all PPA variants in comparison with the AD group on the ACE-R whereas only the svPPA and naPPA groups differed from AD on the FRS.

CONCLUSIONS: The longitudinal profile differs across PPA syndromes on cognitive and functional measures. Findings have theoretical implications and are relevant to the care of patients with dementia.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Issue number2
Publication statusPublished - 2012


  • Aged
  • Alzheimer Disease/diagnosis
  • Aphasia, Primary Progressive/diagnosis
  • Disease Progression
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Primary Progressive Nonfluent Aphasia/diagnosis

Cite this