Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development

Caroline Gray, David Bratt, Julie Lees, Marc daCosta, Karen Plant, Oliver J Watson, Sara Solaymani-Kohal, Simon Tazzyman, Jovana Serbanovic-Canic, David C Crossman, Bernard D Keavney, Andrea Haase, Kathryn McMahon, Martin Gering, Henry Roehl, Paul C Evans, Timothy J A Chico

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Coarctation of the aorta is rarely associated with known gene defects. Blomstrand chondrodysplasia, caused by mutations in the parathyroid hormone receptor 1 (PTHR1) is associated with coarctation of the aorta in some cases, although it is unclear whether PTHR1 deficiency causes coarctation of the aorta directly. The zebrafish allows the study of vascular development using approaches not possible in other models. We therefore examined the effect of loss of function of PTHR1 or its ligand parathyroid hormone-related peptide (PTHrP) on aortic formation in zebrafish.
Original languageEnglish
Pages (from-to)1257-63
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume33
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Animals
  • Aorta
  • Aortic Coarctation
  • Female
  • Gene Expression Regulation, Developmental
  • Homeodomain Proteins
  • Male
  • Models, Animal
  • Mutation
  • Neovascularization, Physiologic
  • Nerve Tissue Proteins
  • Receptor, Notch1
  • Receptor, Parathyroid Hormone, Type 1
  • Reference Values
  • Signal Transduction
  • Up-Regulation
  • Zebrafish
  • Zebrafish Proteins

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