Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development

Caroline Gray; David Bratt; Julie Lees; Marc daCosta; Karen Plant; Oliver J Watson; Sara Solaymani-Kohal; Simon Tazzyman; Jovana Serbanovic-Canic; David C Crossman; Bernard D Keavney; Andrea Haase; Kathryn McMahon; Martin Gering; Henry Roehl; Paul C Evans; Timothy J A Chico

doi:10.1161/ATVBAHA.112.300590

Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development

Caroline Gray, David Bratt, Julie Lees, Marc daCosta, Karen Plant, Oliver J Watson, Sara Solaymani-Kohal, Simon Tazzyman, Jovana Serbanovic-Canic, David C Crossman, Bernard D Keavney, Andrea Haase, Kathryn McMahon, Martin Gering, Henry Roehl, Paul C Evans, Timothy J A Chico

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Coarctation of the aorta is rarely associated with known gene defects. Blomstrand chondrodysplasia, caused by mutations in the parathyroid hormone receptor 1 (PTHR1) is associated with coarctation of the aorta in some cases, although it is unclear whether PTHR1 deficiency causes coarctation of the aorta directly. The zebrafish allows the study of vascular development using approaches not possible in other models. We therefore examined the effect of loss of function of PTHR1 or its ligand parathyroid hormone-related peptide (PTHrP) on aortic formation in zebrafish.

Original language	English
Pages (from-to)	1257-63
Number of pages	7
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	33
Issue number	6
DOIs	https://doi.org/10.1161/ATVBAHA.112.300590
Publication status	Published - Jun 2013

Keywords

Animals
Aorta
Aortic Coarctation
Female
Gene Expression Regulation, Developmental
Homeodomain Proteins
Male
Models, Animal
Mutation
Neovascularization, Physiologic
Nerve Tissue Proteins
Receptor, Notch1
Receptor, Parathyroid Hormone, Type 1
Reference Values
Signal Transduction
Up-Regulation
Zebrafish
Zebrafish Proteins

Access to Document

10.1161/ATVBAHA.112.300590

Cite this

Gray, C., Bratt, D., Lees, J., daCosta, M., Plant, K., Watson, O. J., Solaymani-Kohal, S., Tazzyman, S., Serbanovic-Canic, J., Crossman, D. C., Keavney, B. D., Haase, A., McMahon, K., Gering, M., Roehl, H., Evans, P. C., & Chico, T. J. A. (2013). Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(6), 1257-63. https://doi.org/10.1161/ATVBAHA.112.300590

Gray, Caroline ; Bratt, David ; Lees, Julie ; daCosta, Marc ; Plant, Karen ; Watson, Oliver J ; Solaymani-Kohal, Sara ; Tazzyman, Simon ; Serbanovic-Canic, Jovana ; Crossman, David C ; Keavney, Bernard D ; Haase, Andrea ; McMahon, Kathryn ; Gering, Martin ; Roehl, Henry ; Evans, Paul C ; Chico, Timothy J A. / Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2013 ; Vol. 33, No. 6. pp. 1257-63.

@article{4a72723b77b645ed9f3416643dffbc50,

title = "Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development",

abstract = "Coarctation of the aorta is rarely associated with known gene defects. Blomstrand chondrodysplasia, caused by mutations in the parathyroid hormone receptor 1 (PTHR1) is associated with coarctation of the aorta in some cases, although it is unclear whether PTHR1 deficiency causes coarctation of the aorta directly. The zebrafish allows the study of vascular development using approaches not possible in other models. We therefore examined the effect of loss of function of PTHR1 or its ligand parathyroid hormone-related peptide (PTHrP) on aortic formation in zebrafish.",

keywords = "Animals, Aorta, Aortic Coarctation, Female, Gene Expression Regulation, Developmental, Homeodomain Proteins, Male, Models, Animal, Mutation, Neovascularization, Physiologic, Nerve Tissue Proteins, Receptor, Notch1, Receptor, Parathyroid Hormone, Type 1, Reference Values, Signal Transduction, Up-Regulation, Zebrafish, Zebrafish Proteins",

author = "Caroline Gray and David Bratt and Julie Lees and Marc daCosta and Karen Plant and Watson, {Oliver J} and Sara Solaymani-Kohal and Simon Tazzyman and Jovana Serbanovic-Canic and Crossman, {David C} and Keavney, {Bernard D} and Andrea Haase and Kathryn McMahon and Martin Gering and Henry Roehl and Evans, {Paul C} and Chico, {Timothy J A}",

year = "2013",

month = jun,

doi = "10.1161/ATVBAHA.112.300590",

language = "English",

volume = "33",

pages = "1257--63",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott, Williams and Wilkins",

number = "6",

}

Gray, C, Bratt, D, Lees, J, daCosta, M, Plant, K, Watson, OJ, Solaymani-Kohal, S, Tazzyman, S, Serbanovic-Canic, J, Crossman, DC, Keavney, BD, Haase, A, McMahon, K, Gering, M, Roehl, H, Evans, PC & Chico, TJA 2013, 'Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, no. 6, pp. 1257-63. https://doi.org/10.1161/ATVBAHA.112.300590

Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development. / Gray, Caroline; Bratt, David; Lees, Julie; daCosta, Marc; Plant, Karen; Watson, Oliver J; Solaymani-Kohal, Sara; Tazzyman, Simon; Serbanovic-Canic, Jovana; Crossman, David C; Keavney, Bernard D; Haase, Andrea; McMahon, Kathryn; Gering, Martin; Roehl, Henry; Evans, Paul C; Chico, Timothy J A.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33, No. 6, 06.2013, p. 1257-63.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Loss of function of parathyroid hormone receptor 1 induces Notch-dependent aortic defects during zebrafish vascular development

AU - Gray, Caroline

AU - Bratt, David

AU - Lees, Julie

AU - daCosta, Marc

AU - Plant, Karen

AU - Watson, Oliver J

AU - Solaymani-Kohal, Sara

AU - Tazzyman, Simon

AU - Serbanovic-Canic, Jovana

AU - Crossman, David C

AU - Keavney, Bernard D

AU - Haase, Andrea

AU - McMahon, Kathryn

AU - Gering, Martin

AU - Roehl, Henry

AU - Evans, Paul C

AU - Chico, Timothy J A

PY - 2013/6

Y1 - 2013/6

N2 - Coarctation of the aorta is rarely associated with known gene defects. Blomstrand chondrodysplasia, caused by mutations in the parathyroid hormone receptor 1 (PTHR1) is associated with coarctation of the aorta in some cases, although it is unclear whether PTHR1 deficiency causes coarctation of the aorta directly. The zebrafish allows the study of vascular development using approaches not possible in other models. We therefore examined the effect of loss of function of PTHR1 or its ligand parathyroid hormone-related peptide (PTHrP) on aortic formation in zebrafish.

AB - Coarctation of the aorta is rarely associated with known gene defects. Blomstrand chondrodysplasia, caused by mutations in the parathyroid hormone receptor 1 (PTHR1) is associated with coarctation of the aorta in some cases, although it is unclear whether PTHR1 deficiency causes coarctation of the aorta directly. The zebrafish allows the study of vascular development using approaches not possible in other models. We therefore examined the effect of loss of function of PTHR1 or its ligand parathyroid hormone-related peptide (PTHrP) on aortic formation in zebrafish.

KW - Animals

KW - Aorta

KW - Aortic Coarctation

KW - Female

KW - Gene Expression Regulation, Developmental

KW - Homeodomain Proteins

KW - Male

KW - Models, Animal

KW - Mutation

KW - Neovascularization, Physiologic

KW - Nerve Tissue Proteins

KW - Receptor, Notch1

KW - Receptor, Parathyroid Hormone, Type 1

KW - Reference Values

KW - Signal Transduction

KW - Up-Regulation

KW - Zebrafish

KW - Zebrafish Proteins

U2 - 10.1161/ATVBAHA.112.300590

DO - 10.1161/ATVBAHA.112.300590

M3 - Article

C2 - 23559631

VL - 33

SP - 1257

EP - 1263

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 6

ER -