Low-grade liposarcoma with osteosarcomatous dedifferentiation: radiological and histological features

Andoni P Toms; Lawrence M White; Rita Kandel; Robert S Bell

doi:10.1007/s00256-002-0614-9

Low-grade liposarcoma with osteosarcomatous dedifferentiation: radiological and histological features

Andoni P Toms, Lawrence M White, Rita Kandel, Robert S Bell

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

We describe the radiological and pathological findings of a rare case of a low-grade liposarcoma associated with a high-grade osteosarcomatous component in a 78-year-old woman. Pre-operative imaging demonstrated a well-encapsulated homogeneous fatty tumour in the right buttock deep to the gluteal musculature. Centrally within the fatty tumour a region of increased soft tissue attenuation on CT and heterogeneous high signal on fat-saturated T2-weighted MRI was seen with amorphous calcification/ossification. Histological assessment revealed a low-grade liposarcoma containing an area of dedifferentiation that resembled an osteosarcoma. We describe the radiological-pathological findings in this rarely reported clinical entity and discuss the differential diagnosis of calcification within lipomatous tumours.

Original language	English
Pages (from-to)	286-289
Number of pages	4
Journal	Skeletal Radiology
Volume	32
Issue number	5
DOIs	https://doi.org/10.1007/s00256-002-0614-9
Publication status	Published - May 2003

Keywords

Aged
Buttocks
Calcinosis
Female
Humans
Liposarcoma
Muscle Neoplasms
Muscle, Skeletal

Access to Document

10.1007/s00256-002-0614-9

Cite this

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title = "Low-grade liposarcoma with osteosarcomatous dedifferentiation: radiological and histological features",

abstract = "We describe the radiological and pathological findings of a rare case of a low-grade liposarcoma associated with a high-grade osteosarcomatous component in a 78-year-old woman. Pre-operative imaging demonstrated a well-encapsulated homogeneous fatty tumour in the right buttock deep to the gluteal musculature. Centrally within the fatty tumour a region of increased soft tissue attenuation on CT and heterogeneous high signal on fat-saturated T2-weighted MRI was seen with amorphous calcification/ossification. Histological assessment revealed a low-grade liposarcoma containing an area of dedifferentiation that resembled an osteosarcoma. We describe the radiological-pathological findings in this rarely reported clinical entity and discuss the differential diagnosis of calcification within lipomatous tumours.",

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T1 - Low-grade liposarcoma with osteosarcomatous dedifferentiation

T2 - radiological and histological features

AU - Toms, Andoni P

AU - White, Lawrence M

AU - Kandel, Rita

AU - Bell, Robert S

PY - 2003/5

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N2 - We describe the radiological and pathological findings of a rare case of a low-grade liposarcoma associated with a high-grade osteosarcomatous component in a 78-year-old woman. Pre-operative imaging demonstrated a well-encapsulated homogeneous fatty tumour in the right buttock deep to the gluteal musculature. Centrally within the fatty tumour a region of increased soft tissue attenuation on CT and heterogeneous high signal on fat-saturated T2-weighted MRI was seen with amorphous calcification/ossification. Histological assessment revealed a low-grade liposarcoma containing an area of dedifferentiation that resembled an osteosarcoma. We describe the radiological-pathological findings in this rarely reported clinical entity and discuss the differential diagnosis of calcification within lipomatous tumours.

AB - We describe the radiological and pathological findings of a rare case of a low-grade liposarcoma associated with a high-grade osteosarcomatous component in a 78-year-old woman. Pre-operative imaging demonstrated a well-encapsulated homogeneous fatty tumour in the right buttock deep to the gluteal musculature. Centrally within the fatty tumour a region of increased soft tissue attenuation on CT and heterogeneous high signal on fat-saturated T2-weighted MRI was seen with amorphous calcification/ossification. Histological assessment revealed a low-grade liposarcoma containing an area of dedifferentiation that resembled an osteosarcoma. We describe the radiological-pathological findings in this rarely reported clinical entity and discuss the differential diagnosis of calcification within lipomatous tumours.

KW - Aged

KW - Buttocks

KW - Calcinosis

KW - Female

KW - Humans

KW - Liposarcoma

KW - Muscle Neoplasms

KW - Muscle, Skeletal

U2 - 10.1007/s00256-002-0614-9

DO - 10.1007/s00256-002-0614-9

M3 - Article

C2 - 12679843

VL - 32

SP - 286

EP - 289

JO - Skeletal Radiology

JF - Skeletal Radiology

SN - 0364-2348

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