Low-grade liposarcoma with osteosarcomatous dedifferentiation: radiological and histological features

Andoni P Toms, Lawrence M White, Rita Kandel, Robert S Bell

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17 Citations (Scopus)


We describe the radiological and pathological findings of a rare case of a low-grade liposarcoma associated with a high-grade osteosarcomatous component in a 78-year-old woman. Pre-operative imaging demonstrated a well-encapsulated homogeneous fatty tumour in the right buttock deep to the gluteal musculature. Centrally within the fatty tumour a region of increased soft tissue attenuation on CT and heterogeneous high signal on fat-saturated T2-weighted MRI was seen with amorphous calcification/ossification. Histological assessment revealed a low-grade liposarcoma containing an area of dedifferentiation that resembled an osteosarcoma. We describe the radiological-pathological findings in this rarely reported clinical entity and discuss the differential diagnosis of calcification within lipomatous tumours.
Original languageEnglish
Pages (from-to)286-289
Number of pages4
JournalSkeletal Radiology
Issue number5
Publication statusPublished - May 2003


  • Aged
  • Buttocks
  • Calcinosis
  • Female
  • Humans
  • Liposarcoma
  • Muscle Neoplasms
  • Muscle, Skeletal

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