Abstract
Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.
Original language | English |
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Pages (from-to) | 88-91 |
Number of pages | 4 |
Journal | International Journal of Antimicrobial Agents |
Volume | 23 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2004 |
Keywords
- Enterococcus
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Oxazolidinones
- Staphylococcal Infections
- Staphylococcus