Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563

Mark W Stockdale, Luke Tysall, Alan P Johnson, David M Livermore, Neil Woodford

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5 Citations (Scopus)

Abstract

Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.
Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume23
Issue number1
Publication statusPublished - Jan 2004

Keywords

  • Enterococcus
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutation
  • Oxazolidinones
  • Staphylococcal Infections
  • Staphylococcus

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