Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563

Mark W. Stockdale; Luke Tysall; Alan P. Johnson; David M. Livermore; Neil Woodford

doi:10.1016/j.ijantimicag.2003.06.004

Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563

Mark W. Stockdale
, Luke Tysall
, Alan P. Johnson
, David M. Livermore
, Neil Woodford

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.

Original language	English
Pages (from-to)	88-91
Number of pages	4
Journal	International Journal of Antimicrobial Agents
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.ijantimicag.2003.06.004
Publication status	Published - Jan 2004

Keywords

Enterococcus
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation
Oxazolidinones
Staphylococcal Infections
Staphylococcus

Access to Document

10.1016/j.ijantimicag.2003.06.004

Cite this

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title = "Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563",

abstract = "Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.",

keywords = "Enterococcus, Microbial Sensitivity Tests, Molecular Sequence Data, Mutation, Oxazolidinones, Staphylococcal Infections, Staphylococcus",

author = "Stockdale, \{Mark W.\} and Luke Tysall and Johnson, \{Alan P.\} and Livermore, \{David M.\} and Neil Woodford",

year = "2004",

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language = "English",

volume = "23",

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journal = "International Journal of Antimicrobial Agents",

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T1 - Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563

AU - Stockdale, Mark W.

AU - Tysall, Luke

AU - Johnson, Alan P.

AU - Livermore, David M.

AU - Woodford, Neil

PY - 2004/1

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AB - Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.

KW - Enterococcus

KW - Microbial Sensitivity Tests

KW - Molecular Sequence Data

KW - Mutation

KW - Oxazolidinones

KW - Staphylococcal Infections

KW - Staphylococcus

U2 - 10.1016/j.ijantimicag.2003.06.004

DO - 10.1016/j.ijantimicag.2003.06.004

M3 - Article

C2 - 14732320

SN - 0924-8579

VL - 23

SP - 88

EP - 91

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 1

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