Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

Gregory Livshits, Maria Popham, Ida Malkin, Philip N Sambrook, Alex J Macgregor, Timothy Spector, Frances M K Williams, Alexander Macgregor

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339 Citations (Scopus)


Low back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population. Material and
Original languageEnglish
Pages (from-to)1740-5
Number of pages6
JournalAnnals of the Rheumatic Diseases
Issue number10
Publication statusPublished - Oct 2011


  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Diseases in Twins
  • Female
  • Genetic Predisposition to Disease
  • Great Britain
  • Humans
  • Intervertebral Disc Degeneration
  • Low Back Pain
  • Lumbar Vertebrae
  • Magnetic Resonance Imaging
  • Middle Aged
  • Overweight
  • Risk Factors
  • Young Adult

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