Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

Joseph C. Bear; P. Stephen Patrick; Alfred Casson; Paul Southern; Fang-Yu Lin; Michael J. Powell; Quentin A. Pankhurst; Tammy Kalber; Mark Lythgoe; Ivan P. Parkin; Andrew G. Mayes

doi:10.1038/srep34271

Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

Joseph C. Bear, P. Stephen Patrick, Alfred Casson, Paul Southern, Fang-Yu Lin, Michael J. Powell, Quentin A. Pankhurst, Tammy Kalber, Mark Lythgoe, Ivan P. Parkin, Andrew G. Mayes

Research output: Contribution to journal › Article › peer-review

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Abstract

Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it’s drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane- superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.

Original language	English
Article number	34271
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep34271
Publication status	Published - 27 Sept 2016

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Cite this

@article{4375243b8af443c89f1906f3bf203990,

title = "Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection",

abstract = "Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it{\textquoteright}s drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane- superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.",

author = "Bear, {Joseph C.} and Patrick, {P. Stephen} and Alfred Casson and Paul Southern and Fang-Yu Lin and Powell, {Michael J.} and Pankhurst, {Quentin A.} and Tammy Kalber and Mark Lythgoe and Parkin, {Ivan P.} and Mayes, {Andrew G.}",

note = " This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article{\textquoteright}s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/",

year = "2016",

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doi = "10.1038/srep34271",

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AU - Bear, Joseph C.

AU - Patrick, P. Stephen

AU - Casson, Alfred

AU - Southern, Paul

AU - Lin, Fang-Yu

AU - Powell, Michael J.

AU - Pankhurst, Quentin A.

AU - Kalber, Tammy

AU - Lythgoe, Mark

AU - Parkin, Ivan P.

AU - Mayes, Andrew G.

N1 - This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PY - 2016/9/27

Y1 - 2016/9/27

N2 - Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it’s drug payload. Effective targeted drug delivery systems often rely on external stimuli to effect release, therefore knowing the exact location of the capsule and when to apply an external stimulus is paramount. We present a drug delivery system for the GI tract based on coating standard gelatin drug capsules with a model eicosane- superparamagnetic iron oxide nanoparticle composite coating, which is activated using magnetic hyperthermia as an on-demand release mechanism to heat and melt the coating. We also show that the capsules can be readily detected via rapid X-ray computed tomography (CT) and magnetic resonance imaging (MRI), vital for progressing such a system towards clinical applications. This also offers the opportunity to image the dispersion of the drug payload post release. These imaging techniques also influenced capsule content and design and the delivered dosage form. The ability to easily change design demonstrates the versatility of this system, a vital advantage for modern, patient-specific medicine.

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