Malonic acid half oxyesters and thioesters: Solvent-free synthesis and DFT analysis of their enols

Sean P. Bew, G. Richard Stephenson, Jacques Rouden, Luis A. Martinez-Lozano, Haseena Seylani

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A much improved synthetic route to malonic acid half thioesters (MAHTs) and oxyesters (MAHOs), the easy incorporation of deuterium labeling expecially in MAHTs, and an unexpectedly large difference in enolization chemistry between MAHTs and MAHOs are reported. Density functional theory calculations explore the origins of this difference and identify an additional MAHT molecular orbital which increases delocalization between sulfur and the enol in both cisoid and transoid forms.
Original languageEnglish
Pages (from-to)3805-3807
Number of pages3
JournalOrganic Letters
Issue number15
Publication statusPublished - 2 Aug 2013

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