Many routes to the same destination: lessons from skeletal muscle development

Gi Fay Mok, Dylan Sweetman

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The development and differentiation of vertebrate skeletal muscle provide an important paradigm to understand the inductive signals and molecular events controlling differentiation of specific cell types. Recent findings show that a core transcriptional network, initiated by the myogenic regulatory factors (MRFs; MYF5, MYOD, myogenin and MRF4), is activated by separate populations of cells in embryos in response to various signalling pathways. This review will highlight how cells from multiple distinct starting points can converge on a common set of regulators to generate skeletal muscle.

Original languageEnglish
Pages (from-to)301-312
Number of pages12
JournalReproduction
Volume141
Early online date23 Dec 2010
DOIs
Publication statusPublished - 1 Mar 2011

Keywords

  • Animals
  • Extremities
  • Gene Regulatory Networks
  • Head
  • Humans
  • Models, Biological
  • Muscle Development
  • Muscle, Skeletal
  • Neck
  • Signal Transduction
  • Vertebrates

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