Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

Yingchang Lu, Anika Vaarhorst, Audrey H H Merry, Martijn E T Dollé, Robert Hovenier, Sandra Imholz, Leo J Schouten, Bastiaan T Heijmans, Michael Müller, P Eline Slagboom, Piet A van den Brandt, Anton P M Gorgels, Jolanda M A Boer, Edith J M Feskens

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45 Citations (Scopus)

Abstract

Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are markers of endogenous δ-5 and δ-6 desaturase activities, but have never been studied in relation to incident CHD. Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence.
Original languageEnglish
Article numbere41681
JournalPLoS One
Volume7
Issue number7
DOIs
Publication statusPublished - 23 Jul 2012

Keywords

  • Adult
  • Biological Markers
  • Cholesterol Esters
  • Cohort Studies
  • Coronary Artery Disease
  • Fatty Acid Desaturases
  • Fatty Acids, Unsaturated
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Netherlands
  • Polymorphism, Single Nucleotide
  • Risk Factors

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