Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

Yingchang Lu; Anika Vaarhorst; Audrey H. H. Merry; Martijn E. T. Dollé; Robert Hovenier; Sandra Imholz; Leo J. Schouten; Bastiaan T. Heijmans; Michael Müller; P Eline Slagboom; Piet A. van den Brandt; Anton P. M. Gorgels; Jolanda M. A. Boer; Edith J. M. Feskens

doi:10.1371/journal.pone.0041681

Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

Yingchang Lu, Anika Vaarhorst, Audrey H. H. Merry, Martijn E. T. Dollé, Robert Hovenier, Sandra Imholz, Leo J. Schouten, Bastiaan T. Heijmans, Michael Müller, P Eline Slagboom, Piet A. van den Brandt, Anton P. M. Gorgels, Jolanda M. A. Boer, Edith J. M. Feskens

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are markers of endogenous δ-5 and δ-6 desaturase activities, but have never been studied in relation to incident CHD. Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence.

Original language	English
Article number	e41681
Journal	PLoS One
Volume	7
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0041681
Publication status	Published - 23 Jul 2012

Keywords

Adult
Biological Markers
Cholesterol Esters
Cohort Studies
Coronary Artery Disease
Fatty Acid Desaturases
Fatty Acids, Unsaturated
Female
Genetic Predisposition to Disease
Humans
Incidence
Male
Middle Aged
Netherlands
Polymorphism, Single Nucleotide
Risk Factors

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Cite this

Lu, Y., Vaarhorst, A., Merry, A. H. H., Dollé, M. E. T., Hovenier, R., Imholz, S., Schouten, L. J., Heijmans, B. T., Müller, M., Slagboom, P. E., van den Brandt, P. A., Gorgels, A. P. M., Boer, J. M. A., & Feskens, E. J. M. (2012). Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. PLoS One, 7(7), [e41681]. https://doi.org/10.1371/journal.pone.0041681

Lu, Yingchang ; Vaarhorst, Anika ; Merry, Audrey H. H. ; Dollé, Martijn E. T. ; Hovenier, Robert ; Imholz, Sandra ; Schouten, Leo J. ; Heijmans, Bastiaan T. ; Müller, Michael ; Slagboom, P Eline ; van den Brandt, Piet A. ; Gorgels, Anton P. M. ; Boer, Jolanda M. A. ; Feskens, Edith J. M. / Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. In: PLoS One. 2012 ; Vol. 7, No. 7.

@article{8108471dee444fc29d98d57469fee456,

title = "Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study",

abstract = "Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are markers of endogenous δ-5 and δ-6 desaturase activities, but have never been studied in relation to incident CHD. Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence.",

keywords = "Adult, Biological Markers, Cholesterol Esters, Cohort Studies, Coronary Artery Disease, Fatty Acid Desaturases, Fatty Acids, Unsaturated, Female, Genetic Predisposition to Disease, Humans, Incidence, Male, Middle Aged, Netherlands, Polymorphism, Single Nucleotide, Risk Factors",

author = "Yingchang Lu and Anika Vaarhorst and Merry, {Audrey H. H.} and Doll{\'e}, {Martijn E. T.} and Robert Hovenier and Sandra Imholz and Schouten, {Leo J.} and Heijmans, {Bastiaan T.} and Michael M{\"u}ller and Slagboom, {P Eline} and {van den Brandt}, {Piet A.} and Gorgels, {Anton P. M.} and Boer, {Jolanda M. A.} and Feskens, {Edith J. M.}",

year = "2012",

month = jul,

day = "23",

doi = "10.1371/journal.pone.0041681",

language = "English",

volume = "7",

journal = "PLoS One",

issn = "1932-6203",

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Lu, Y, Vaarhorst, A, Merry, AHH, Dollé, MET, Hovenier, R, Imholz, S, Schouten, LJ, Heijmans, BT, Müller, M, Slagboom, PE, van den Brandt, PA, Gorgels, APM, Boer, JMA & Feskens, EJM 2012, 'Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study', PLoS One, vol. 7, no. 7, e41681. https://doi.org/10.1371/journal.pone.0041681

Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. / Lu, Yingchang; Vaarhorst, Anika; Merry, Audrey H. H.; Dollé, Martijn E. T.; Hovenier, Robert; Imholz, Sandra; Schouten, Leo J.; Heijmans, Bastiaan T.; Müller, Michael; Slagboom, P Eline; van den Brandt, Piet A.; Gorgels, Anton P. M.; Boer, Jolanda M. A.; Feskens, Edith J. M.

In: PLoS One, Vol. 7, No. 7, e41681, 23.07.2012.

Research output: Contribution to journal › Article › peer-review

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T1 - Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

AU - Lu, Yingchang

AU - Vaarhorst, Anika

AU - Merry, Audrey H. H.

AU - Dollé, Martijn E. T.

AU - Hovenier, Robert

AU - Imholz, Sandra

AU - Schouten, Leo J.

AU - Heijmans, Bastiaan T.

AU - Müller, Michael

AU - Slagboom, P Eline

AU - van den Brandt, Piet A.

AU - Gorgels, Anton P. M.

AU - Boer, Jolanda M. A.

AU - Feskens, Edith J. M.

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N2 - Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are markers of endogenous δ-5 and δ-6 desaturase activities, but have never been studied in relation to incident CHD. Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence.

AB - Intakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain unclear. δ-5 and δ-6 desaturases are rate-limiting enzymes for synthesizing long-chain n-3 and n-6 PUFAs. C20:4n-6 to C20:3n-6 and C18:3n-6 to C18:2n-6 ratios are markers of endogenous δ-5 and δ-6 desaturase activities, but have never been studied in relation to incident CHD. Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence.

KW - Adult

KW - Biological Markers

KW - Cholesterol Esters

KW - Cohort Studies

KW - Coronary Artery Disease

KW - Fatty Acid Desaturases

KW - Fatty Acids, Unsaturated

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Netherlands

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

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DO - 10.1371/journal.pone.0041681

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